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IJC-B Vol.51B(03) [March 2012] >

Title: Synthesis of 5-oxo-1-substituted tetrazoles derived from amino acids
Authors: Nagendra, G
Narendra, N
Sureshbabu, Vommina V
Keywords: Tetrazole
Issue Date: Mar-2012
Publisher: NISCAIR-CSIR, India
Abstract: Herein is described an application of amino acid derived isocyanates in the synthesis of 5-oxo-tetrazoles. A series of 1-substituted tetrazol-5-ones have been synthesized by [3+2] cycloaddition of N-Fmoc/Boc/Cbz protected β-amino acid derived isocyanates and TMS-N3. The protocol has also been extended for the insertion of oxo-tetrazolone moiety in the side chains of the Asp/Glu by employing oxazolidinone bidentate protection for Cα and Nα groups.
Page(s): 486-492
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
Source:IJC-B Vol.51B(03) [March 2012]

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