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|Title:||Synthesis of 5-oxo-1-substituted tetrazoles derived from amino acids|
Sureshbabu, Vommina V
|Abstract:||Herein is described an application of amino acid derived isocyanates in the synthesis of 5-oxo-tetrazoles. A series of 1-substituted tetrazol-5-ones have been synthesized by [3+2] cycloaddition of N-Fmoc/Boc/Cbz protected β<i>-</i>amino acid derived isocyanates and TMS-N<sub>3</sub>. The protocol has also been extended for the insertion of oxo-tetrazolone moiety in the side chains of the Asp/Glu by employing oxazolidinone bidentate protection for <i style="">C<sup>α</sup></i><sup> </sup>and <i style="">N<sup>α</sup></i><sup> </sup>groups.|
|Appears in Collections:||IJC-B Vol.51B(03) [March 2012]|
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