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http://nopr.niscair.res.in/handle/123456789/13694
Title: | Synthesis of 5-oxo-1-substituted tetrazoles derived from amino acids |
Authors: | Nagendra, G Narendra, N Sureshbabu, Vommina V |
Keywords: | Tetrazole;Tetrazolone;Isocyanate;Oxazolidinone;Cycloaddition |
Issue Date: | Mar-2012 |
Publisher: | NISCAIR-CSIR, India |
Abstract: | Herein is described an application of amino acid derived isocyanates in the synthesis of 5-oxo-tetrazoles. A series of 1-substituted tetrazol-5-ones have been synthesized by [3+2] cycloaddition of N-Fmoc/Boc/Cbz protected β-amino acid derived isocyanates and TMS-N3. The protocol has also been extended for the insertion of oxo-tetrazolone moiety in the side chains of the Asp/Glu by employing oxazolidinone bidentate protection for Cα and Nα groups. |
Page(s): | 486-492 |
URI: | http://hdl.handle.net/123456789/13694 |
Appears in Collections: | IJC-B Vol.51B(03) [March 2012] |
Files in This Item:
File | Description | Size | Format | |
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IJCB 51B(3) 486-492.pdf | 104.87 kB | Adobe PDF | View/Open |
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