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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(03) [March 2012] >
| Title: | Synthesis of 5-oxo-1-substituted tetrazoles derived from amino acids |
| Authors: | Nagendra, G
Narendra, N
Sureshbabu, Vommina V |
| Keywords: | Tetrazole
Tetrazolone
Isocyanate
Oxazolidinone
Cycloaddition |
| Issue Date: | Mar-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Herein is described an application of amino acid derived isocyanates in the synthesis of
5-oxo-tetrazoles. A series of 1-substituted tetrazol-5-ones have been
synthesized by [3+2] cycloaddition of N-Fmoc/Boc/Cbz protected β-amino acid derived
isocyanates and TMS-N3. The protocol has also been extended for the
insertion of oxo-tetrazolone moiety in the side chains of the Asp/Glu by
employing oxazolidinone bidentate protection for Cα and Nα
groups. |
| Page(s): | 486-492 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| Source: | IJC-B Vol.51B(03) [March 2012]
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