Anti-inflammatory, analgesic and antioxidant potential of the stem bark of Amra (<i>Spondias mangifera </i>Willd.)

Abstract

The anti-inflammatory and analgesic activities of ethyl acetate (EAFSM) and n-butanol (NBFSM) fractions of alcoholic extract of <i>S. mangifera </i>bark were evaluated by using carrageenan induced rat paw edema and by tail-flick method in rats. The radical scavenging activity of ethanolic extract, aqueous extract and fractions was determined by using DPPH radical scavenging capacity assay. Two fractions of the alcoholic extract, EAFSM and NBFSM at the dose of 75, 150 & 300 mg/kg b.w. orally after overnight fasting, showed significant reduction in paw volume when compared with respective control group of carrageenan challenge. Different doses of extract fractions also showed significant prolongation of tail-flick latency of rat (P<0.01). Different concentrations of alcoholic, aqueous extracts and fractions of alcoholic extract showed significant free radical scavenging capacity against DPPH generated free radicals.