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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Research Journals >
Bharatiya Vaigyanik evam Audyogik Anusandhan Patrika (BVAAP) >
BVAAP Vol.19 [2011] >
BVAAP Vol.19(2) [December 2011] >
| Title: | Evaluation of radioprotective effect of unripe stone fruit pulp extract on liver |
| Authors: | Arya, Sunita
Sharma, Jaimala |
| Issue Date: | Dec-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | To
find out natural plant based radioprotectors, a well known medicinal plant,
which is acceptable to the body, Aegle marmelos extract (AME), was tested in animals against gamma radiations.
Radioprotective effect of unripe stone fruit pulp extract on some liver enzymes
of Swiss albino mouse were investigated. For experimental study healthy Swiss
albino mice were selected from an inbred colony and divided into two groups and
exposed to 8Gy gamma radiation (control) or 8Gy gamma radiation with 100mg/kg
body weight of Aegle
marmelos extract
(experimental), sham irradiated (normal) and plant extract only. Mice were
sacrificed at various post irradiation intervals and liver was removed for
quantitative estimation of Glutathione (GSH) and Lipid peroxidation (LPO). It
was observed that GSH content decreased significantly on 5th day after exposure
to 8Gy of gamma radiation in control group .Then it started to decrease on 7th
day of the treatment. In the experimental group GSH content was higher as
compared to their corresponding control . The animals which were treated with
only AME showed greater protection. Irradiation resulted an elevation in lipid
peroxidation level in liver. On the other hand, treatment of animals with Aegle marmelos before irradiation caused a significant decrease
in LPO. These results indicate that Aegle marmelos protects from damage to the liver of Swiss albino mouse against of gamma
radiations lethal dose. |
| Page(s): | 125-128 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-2412 (Online); 0771-7706 (Print) |
| Source: | BVAAP Vol.19(2) [December 2011]
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