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Title: An association study of single nucleotide polymorphisms of the FOXP3 intron-1 and the risk of Psoriasis vulgaris
Authors: Song, Qiu-he
Shen, Zhu
Xing, Xiao-jing
Yin, Rui
Wu, Ya-zhou
You, Yi
Guo, Hong
Chen, Ling
Hao, Fei
Bai, Yun
Keywords: Psoriasis Vulgaris
Single Nucleotide Polymorphisms
<i style="">FOXP3 </i>gene
Issue Date: Feb-2012
Publisher: NISCAIR-CSIR, India
Abstract: Psoriasis vulgaris (PV) is a common autoimmune disease that involves the dysfunction of CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells. FOXP3 is a key transcription factor in the development and function of CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells. Previous studies have demonstrated a genetic association between the<i style=""> FOXP3 </i>gene and some autoimmune diseases. To elucidate the association between the <i style="">FOXP3 </i>gene and the risk of PV, 408 patients diagnosed with PV and 363 age and sex-matched healthy controls from a cohort of the Chinese majority Han population were recruited. Four single nucleotide polymorphisms (rs2232365, rs3761547, rs3761548 and rs3761549) of the <i style="">FOXP3</i> gene were analyzed using the polymerase chain reaction and ligase detection reaction. The major allele of three single nucleotide polymorphisms (SNPs — rs2232365 A, rs3761547 A and rs3761549 C) were associated with an increased risk of PV in a clinical subgroup of female patients, who were less than 40 yrs of age, had a family history of the disease and did not have disease complications (<i style="">p</i> < 0.05 for all parameters). The haplotype was structured between rs3761547 and rs3761549. An increased risk of PV was observed in haplotype A/A-T/T (<i style="">p</i> = 0.0055; adjusted OR = 3.188; 95% CI = 0.4354-23.34) and A/G-C/C (<i style="">p</i> = 0.0082; adjusted OR = 1.288; 95% CI = 0.1529-10.85) between rs3761547 and rs3761549. A synergistic effect was found among the three SNPs. Subjects with the rs2232365AA- rs3761547 AG + GG genotype were more susceptible to PV (<i style="">p </i>= 0.0393; OR = 2.90; 95% CI = 1.05-7.97). No correlation was found between rs3761548 and the onset of PV. Therefore, the <i style="">FOXP3</i> polymorphisms appear to contribute to the risk of psoriasis among the Chinese majority Han population. These findings may aid in our understanding of the pathogenesis of psoriasis.
Description: 25-35
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.49(1) [February 2012]

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