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Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.49 [2012] >
IJBB Vol.49(1) [February 2012] >
| Title: | An association study of single nucleotide polymorphisms of the FOXP3 intron-1 and the risk of Psoriasis vulgaris |
| Authors: | Song, Qiu-he
Shen, Zhu
Xing, Xiao-jing
Yin, Rui
Wu, Ya-zhou
You, Yi
Guo, Hong
Chen, Ling
Hao, Fei
Bai, Yun |
| Keywords: | Psoriasis Vulgaris
Single Nucleotide Polymorphisms
Susceptibility
FOXP3 gene
FOX3 mRNA |
| Issue Date: | Feb-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Psoriasis vulgaris (PV) is a common autoimmune disease that involves the
dysfunction of CD4+CD25+ regulatory
T cells. FOXP3 is a key transcription factor in the development and function of
CD4+CD25+ regulatory T cells. Previous studies have
demonstrated a genetic association between the FOXP3 gene and some autoimmune diseases. To elucidate the
association between the FOXP3 gene
and the risk of PV, 408 patients diagnosed with PV and 363 age and sex-matched
healthy controls from a cohort of the Chinese majority Han population were
recruited. Four single nucleotide polymorphisms (rs2232365, rs3761547,
rs3761548 and rs3761549) of the FOXP3
gene were analyzed using the polymerase chain reaction and ligase detection
reaction. The major allele of three single nucleotide polymorphisms (SNPs —
rs2232365 A, rs3761547 A
and rs3761549 C) were
associated with an increased risk of PV in a clinical subgroup of female
patients, who were less than 40 yrs of age, had a family history of the disease
and did not have disease complications (p
< 0.05 for all parameters). The haplotype was structured between rs3761547
and rs3761549. An increased risk of PV was observed in haplotype A/A-T/T (p = 0.0055; adjusted OR = 3.188; 95% CI
= 0.4354-23.34) and A/G-C/C (p =
0.0082; adjusted
OR = 1.288; 95% CI = 0.1529-10.85) between rs3761547 and rs3761549. A
synergistic effect was found among the three SNPs. Subjects with the
rs2232365AA- rs3761547 AG + GG genotype were more susceptible to PV (p = 0.0393;
OR = 2.90; 95% CI = 1.05-7.97). No correlation was found between rs3761548 and
the onset of PV. Therefore, the FOXP3
polymorphisms appear to contribute to the risk of psoriasis among the Chinese
majority Han population. These findings may aid in our understanding of the
pathogenesis of psoriasis. |
| Page(s): | 25-35 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0959 (Online); 0301-1208 (Print) |
| Source: | IJBB Vol.49(1) [February 2012]
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