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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(02) [February 2012] >
| Title: | Developmental and neurobehavioural toxicity study of arsenic on rats following gestational exposure |
| Authors: | Gandhi, D N
Panchal, G M
Patel, K G |
| Keywords: | Arsenic
Development
Gestational Exposure
Neurobehavioural Endpoints
Teratology |
| Issue Date: | Feb-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | To characterize developmental and behavioral alterations induced by arsenic
exposure, Albino rats were exposed to arsenic (0, 1.5, 3.0 and 4.5
mg/kg/day/po) from gestation day 8 to till parturition and the offspring were
observed over the first 3 postnatal weeks, until they were weaned on post-natal
day (PND) 21. Once the pups were delivered (PND0), the treatment was
discontinued. All pups were assessed for physical development, reflex
development, strength and motor coordination from standard neurobehavioural
developmental test batteries beginning on PND1. Gestational administration of
arsenic at tested dose levels, showed no significant changes in the day of
appearance of eye opening, startle reflex, negative geotaxis and spontaneous
alteration performance in comparison to the control group. The number of live
fetuses, mean fetal body weight and percentages of resorptions or malformations per litter
were not affected by arsenic exposure. No treatment-related malformations or
developmental variations were noted at any exposure level, suggesting that
arsenic exposure at this dose level did not adversely affect behavioural
endpoints of developmental toxicity. |
| Page(s): | 147-155 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(02) [February 2012]
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