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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(02) [February 2012] >
| Title: | Protective effect of Tribulus terrestris linn on liver and kidney in cadmium intoxicated rats |
| Authors: | Lakshmi, G Dhana
Kumar, P Ravi
Bharavi, K
Annapurna, P
Rajendar, B
Patel, Pankaj T |
| Keywords: | Cadmium
Kidney
Liver
Rats
Tribulus Terrestris |
| Issue Date: | Feb-2012 |
| Publisher: | CSIR |
| Abstract: | Administration of cadmium (Cd) significantly increased the peroxidation
markers such as malondialdehyde and protein carbonyls along with significant
decrease in antioxidant markers such as super oxide dismutase and reduced
glutathione in liver and kidney tissues. Cadmium also caused a significant alteration
in hepatic and renal functional markers in serum viz. total protein, albumin,
alanine transaminase, blood urea nitrogen and creatinine. Prominent
pathological changes observed in liver were severe vascular and sinusoidal
congestion with diffuse degenerative changes and mononuclear infiltration into
peripheral areas, while the kidney showed vascular and glomerular congestion,
cloudy swelling of tubular epithelium. Co-administration of ethonolic extract
of T. terrestris or vitamin E along
with Cd significantly reversed the Cd induced changes along with significant
reduction in Cd load. |
| Page(s): | 141-146 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(02) [February 2012]
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