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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(02) [February 2012] >
| Title: | Progression of early phase diabetic nephropathy in streptozotocin-induced diabetic rats: Evaluation of various kidney-related parameters |
| Authors: | Kiran, G
Nandini, CD
Ramesh, HP
Salimath, PV |
| Keywords: | Diabetes
Diabetic Nephropathy
Glycosaminoglycans
Microalbuminuria
Type IV Collagen |
| Issue Date: | Feb-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Diabetic nephropathy (DN) is one of the
serious secondary complications of diabetes, which results in end-stage renal
failure. Reports on the progressive nature of early phase DN especially with
respect to kidney parameters such as kidney weight, type IV collagen excretion,
total kidney and urinary glycosaminoglycans (GAGs) are few. This work was
undertaken to determine systematically the progression of early phase DN in
relation to various kidney-related parameters for a period of four months.
Experimentally-induced diabetic rats were grouped based on fasting blood
glucose levels. Various basic and kidney-related parameters such as kidney
weight, microalbuminuria, urinary excretion of GAGs and type IV collagen, total
kidney GAGs, histopathology, glomerular area and glomerular volume were
examined in control and diabetic rats. There was a progressive increase in
fasting blood sugar, urine sugar, kidney weight, microalbuminuria, urine
glycosaminoglycans, urine type IV collagen, glomerular area and glomerular
volume but there was a progressive decrease in kidney glycosaminoglycans.
Glomerular sclerotic condition was aggravated with the increase in duration of diabetes
from 1 to 4 months. Onset of DN in rats begins subtly after one month of
diabetes but gets vitiated and more pronounced at the end of four months. |
| Page(s): | 133-140 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(02) [February 2012]
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