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|Title:||Cold stress interaction on organophosphate insecticide poisoning: Age-related assessment in rat cerebral cortex|
Basha, P Mahaboob
|Keywords:||Cerebral Cortex Enzymes|
|Abstract:||The present study was undertaken to identify the nature of the interactive effects of chlorpyrifos (CPF) and cold stress (15° and 20°C) on the activities of acetyl cholinesterase (AChE), choline acetyl transferase (ChAT), Na<sup>+</sup>, K<sup>+</sup>-ATPase and malondialdehyde (MDA) level in the cerebral cortex of 1 week, 3 weeks and 3 months of age. The results indicated an interaction of CPF with age of animal and cold exposure resulting in marked decrease in the activity levels of AChE, ChAT, Na<sup>+</sup>, K<sup>+</sup>-ATPase, followed by increased MDA levels. Overall, the effects of co-exposure of cold stress and CPF were appreciably different from either of the exposures. However, synergistic-action of CPF and cold stress at 15°C showed a greater inhibition of AChE, ChAT, and Na<sup>+</sup>, K<sup>+</sup>-ATPase in comparison with CPF or cold stress alone and together at 20°C. The results reveal that young animals are markedly more sensitive to interactive effects of CPF and cold stress than adults.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.50(02) [February 2012]|
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