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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(02) [February 2012] >
| Title: | Effect of L-deprenyl treatment on electrical activity, Na+, K+ ATPase, and protein kinase C activities in hippocampal subfields (CA1 and CA3) of aged rat brain |
| Authors: | Singh, Rameshwar
Mishra, Monika
Singh, Sangeeta
Sharma, Deepak |
| Keywords: | Ageing
Hippocampus
L-deprenyl
Multiple Unit Action Potentials
Na+
K+-ATPase
Protein Kinase C |
| Issue Date: | Feb-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | L-deprenyl is considered to protect against
age-related cognitive deficits by improving long-term learning/memory in the
aged brain. The CA1 and CA3 hippocampal areas are the sites at which initial
learning and memory processes occur. Chronic deprenyl treatment significantly augmented the basal electrical firing rate (multiple-unit action potentials),and Na+, K+-ATPase and protein kinase C activities of both CA1 and CA3 indicating that the drug increased the excitability of CA1 and CA3. The increase, however, was much greater in CA1 than in CA3 suggesting that deprenyl can improve longer term learning in aged animals by its excitability-enhancing action in CA1. The drug also countered the ageing-related loss of hippocampal protein kinase C activity. |
| Page(s): | 101-109 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(02) [February 2012]
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