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Title: Synthesis and biological evaluation of some novel 2-mercaptobenzothiazoles carrying 2-pyrazoline
Authors: Azam, Md. Afzal
Suresh, Bhojraj
Keywords: Anti-inflammatory Activity
Antimicrobial Activity
Ulcerogenic Action
Issue Date: Feb-2012
Publisher: NISCAIR-CSIR, India
Abstract: This study presents synthesis of several 2-mercaptobenzothiazole derivatives <b>6a-s </b>bearing 2-pyrazoline at the second position. Compounds <b>6h</b>, <b>6i</b>, <b>6j </b>and <b>6n </b>exhibited significant antimicrobial activity (inhibition zone 30-35 mm) against <i>Pseudomonas aeruginosa</i>. Compounds <b>6i</b>, <b>6j </b>and <b>6n </b>showed significant analgesic and anti-inflammatory activities. Compounds <b>6i </b>and <b>6n </b>showed significant gastrointestinal protection compared to the standard drug diclofenac sodium.
Description: 113-119
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.71(02) [February 2012]

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