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Journal of Scientific and Industrial Research (JSIR) >
JSIR Vol.71 [2012] >
JSIR Vol.71(02) [February 2012] >
| Title: | Synthesis and biological evaluation of some novel 2-mercaptobenzothiazoles carrying 2-pyrazoline |
| Authors: | Azam, Md. Afzal
Suresh, Bhojraj |
| Keywords: | Anti-inflammatory Activity
Antimicrobial Activity
2-Mercaptobenzothiazoles
2-Pyrazolines
Ulcerogenic Action |
| Issue Date: | Feb-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | This study presents
synthesis of several 2-mercaptobenzothiazole derivatives 6a-s bearing
2-pyrazoline at the second position. Compounds 6h, 6i, 6j and
6n exhibited significant antimicrobial activity (inhibition zone 30-35
mm) against Pseudomonas aeruginosa. Compounds 6i, 6j and 6n
showed significant analgesic and anti-inflammatory activities. Compounds 6i
and 6n showed significant gastrointestinal protection compared to
the standard drug diclofenac sodium. |
| Page(s): | 113-119 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Source: | JSIR Vol.71(02) [February 2012]
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