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Indian Journal of Geo-Marine Sciences (IJMS) >
IJMS Vol.41 [2012] >
IJMS Vol.41(1) [February 2012] >
| Title: | Marine natural products: A lead for Anti-cancer |
| Authors: | Sarfaraj, Hussain Md.
Sheeba, Fareed
Saba, Ansari
Khan, Mohd. Sajid |
| Keywords: | Marine natural products
didemnin B
Dolastatin
Bryostatin1
Kahalalide F |
| Issue Date: | Feb-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Various active anticancer agents are derived from plants
and terrestrial microorganisms. Isolation of C-nucleosides from the Caribbean
sponge, Cryptotheca crypta, four decades ago, provided the basis for the
synthesis of cytarabine, the first marine derived anticancer agent to be
developed for clinical use. Cytarabine is currently used in the routine
treatment of patients with leukaemia and lymphoma. Gemcitabine, one of its
fluorinated derivatives, has also been approved for use in patients with
pancreatic, breast, bladder, and non-small-cell lung cancer. Over the past
decade, several new experimental anticancer agents derived from marine sources
have entered preclinical and clinical trials. Present study address anticancer
drug discovery from an evolutionary perspective and present a series of case
studies that demonstrate that the rate of anticancer drug discovery can be increased
greatly by targeted screening of natural compounds from marine sources. |
| Page(s): | 27-39 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1033 (Online); 0379-5136 (Print) |
| Source: | IJMS Vol.41(1) [February 2012]
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