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Title: Microwave assisted synthesis and antibacterial properties of some new 2-alkyl/aryl-(6-substitutedcoumarin-3-yl)imidazo[2,1-b][1,3,4]thiadiazoles
Authors: Jakhar, Anshu
Makrandi, J K
Keywords: Microwave irradiation;2-alkyl/aryl-(6-substitutedcoumarin-3-yl)imidazo [2,1-b][1,3,4]thiadiazoles;3-(2-bromoacetyl)-6-substitutedcoumarins;5-alkyl/aryl-2-amino-1,3,4-thiadiazoles;Antibacterial properties
Issue Date: Jan-2012
Publisher: NISCAIR-CSIR, India
Abstract: A series of 2-alkyl/aryl-(6-substitutedcoumarin-3-yl)imidazo[2,1-b][1,3,4] thiadiazoles 3a-o have been synthesized by reacting 3-(2-bromoacetyl)-6-substitutedcoumarins 1 with various 5-alkyl/aryl-2-amino-1,3,4-thiadiazoles 2 under normal thermal condition as well as microwave irradiation. The latter condition is found to be much more efficient in terms of time and yield. The structures of the newly synthesized compounds have been characterized by elemental analysis, IR and 1H NMR spectral data. All the newly synthesized compounds have been tested for their antibacterial properties against gram-positive and gram-negative bacteria.
Page(s): 291-296
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(01) [January 2012]

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