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Title: Rational design, synthesis, SAR study of N-napthalen-1-yl-2-[4-(substituted phenyl)-piperazin-1-yl]-acetamides as atypical antipsychotic agents
Authors: Sati, N
Kumar, S
Rawat, M S M
Keywords: N-Napthalen-1-yl acetamide
Serotonin antagonists
Dopamine antagonists
Atypical antipsychotic
Issue Date: Jan-2012
Publisher: NISCAIR-CSIR, India
Abstract: Design and synthesis of various N-napthalen-1-yl-2-[4-(substituted phenyl)-piperazin-1-yl]-acetamides have been carried out on the basis of structural information available for dopamine D<sub>3</sub> and serotonin receptor and screened for antagonist activity at the target receptors and atypical antipsychotic profile. The series synthesized affords compounds having varying degree of affinity for target receptors. N-napthalen-1-yl-2-[4-(2-methoxy phenyl)-piperazin-1-yl]-acetamide <b style="mso-bidi-font-weight:normal">1e</b> is found to be the most potent atypical antipsychotic compound synthesized.
Description: 318-322
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.51B(01) [January 2012]

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