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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.51B [2012] >
IJC-B Vol.51B(01) [January 2012] >
| Title: | Rational design, synthesis, SAR study of N-napthalen-1-yl-2-[4-(substituted phenyl)-piperazin-1-yl]-acetamides as atypical antipsychotic agents |
| Authors: | Sati, N
Kumar, S
Rawat, M S M |
| Keywords: | N-Napthalen-1-yl acetamide
Serotonin antagonists
arylpiperazines
Dopamine antagonists
Atypical antipsychotic |
| Issue Date: | Jan-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Design and synthesis of
various N-napthalen-1-yl-2-[4-(substituted phenyl)-piperazin-1-yl]-acetamides
have been carried out on the basis of structural information available for
dopamine D3 and serotonin receptor and screened for antagonist
activity at the target receptors and atypical antipsychotic profile. The series
synthesized affords compounds having varying degree of affinity for target
receptors. N-napthalen-1-yl-2-[4-(2-methoxy phenyl)-piperazin-1-yl]-acetamide 1e is found to be the most potent
atypical antipsychotic compound synthesized. |
| Page(s): | 318-322 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.51B(01) [January 2012]
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