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Title: Role of T-cells in Diabetic Pregnancy and Macrosomia
Authors: Khan, Naim Akhtar
Keywords: T-cells;Inflammation;Peroxisome proliferator-activated receptors;Diabetic pregnancy;Macrosomia
Issue Date: Oct-2007
Publisher: CSIR
Abstract: A number of studies have recently addressed the correlationship between diabetic pregnancy/macrosomia and differentiation of T-cells into Th1 and Th2 subsets. Diabetic pregnancy has been found to be associated with a decreased Th1 phenotype and IL-4 mRNA expression. In macrosomic offspring, high expression of IL-2 and IFN-ϒ mRNA, but not of Th2 cytokines is observed, indicating that the Th1 phenotype is upregulated during macrosomia. T-cells of gestational diabetic rats and their macrosomic offspring seem to present a defect in signal transduction. Indeed, the recruitment of free intracellular calcium concentrations from intracellular pool in T-cells of these animals is altered. The phenotype of regulatory T-cells (T-Reg) is upregulated in diabetic pregnancy and their infants. T-cells in diabetic pregnancy and macrosomic obese offspring are in vivo activated. Adipokines and peroxisome proliferator-activated receptor-⍺ (PPARα) also seem to modulate the pro-inflammatory cytokines in these pathologies. Hence, activation of the immune system might be considered as one of the regulatory pathways including metabolic abnormalities in these two pathologies.
Page(s): 344-349
ISSN: 0301-1208
Appears in Collections:IJBB Vol.44(5) [October 2007]

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