|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Biochemistry and Biophysics (IJBB) >
IJBB Vol.44 [2007] >
IJBB Vol.44(5) [October 2007] >
| Title: | Role of T-cells in Diabetic Pregnancy and Macrosomia |
| Authors: | Khan, Naim Akhtar |
| Keywords: | T-cells
Inflammation
Peroxisome proliferator-activated receptors
Diabetic pregnancy
Macrosomia |
| Issue Date: | Oct-2007 |
| Publisher: | CSIR |
| Abstract: | A number of studies have recently addressed the correlationship between diabetic pregnancy/macrosomia and differentiation of T-cells into Th1 and Th2 subsets. Diabetic pregnancy has been found to be associated with a decreased Th1 phenotype and IL-4 mRNA expression. In macrosomic offspring, high expression of IL-2 and IFN-ϒ mRNA, but not of Th2 cytokines is observed, indicating that the Th1 phenotype is upregulated during macrosomia. T-cells of gestational diabetic rats and their macrosomic offspring seem to present a defect in signal transduction. Indeed, the recruitment of free intracellular calcium concentrations from intracellular pool in T-cells of these animals is altered. The phenotype of regulatory T-cells (T-Reg) is upregulated in diabetic pregnancy and their infants. T-cells in diabetic pregnancy and macrosomic obese offspring are in vivo activated. Adipokines and peroxisome proliferator-activated receptor-⍺ (PPARα) also seem to modulate the pro-inflammatory cytokines in these pathologies. Hence, activation of the immune system might be considered as one of the regulatory pathways including metabolic abnormalities in these two pathologies. |
| Page(s): | 344-349 |
| ISSN: | 0301-1208 |
| Source: | IJBB Vol.44(5) [October 2007]
|
|
