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Indian Journal of Chemistry -Section A (IJC-A) >
IJC-A Vol.51A [2012] >
IJC-A Vol.51A(01-02) [January-February 2012] >
| Title: | NO- and CO-donors: An emerging class of pharmaceuticals in current medicine |
| Authors: | Mascharak, Pradip K |
| Keywords: | Nitric oxide
Carbon monoxide
NO-drugs
CORM
Heme oxygenase
Nitrosyl compounds
Carbonyl compounds
Signal transduction
Cytoprotective activity |
| Issue Date: | Jan-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | In recent
years, two small diatomic molecules namely, nitric oxide (NO) and carbon
monoxide (CO) have been shown to play key roles in human physiology. Depending
on their concentration (in the nano-to-micro molar range), these two molecules
exhibit distinct physiological or pathological effects. Several exogenous
NO-donors have found use as medication for blood pressure control and as
anti-infective agents. CO-donating compounds have shown promises in controlling
tissue damage. Demand for new and efficient NO- and CO-donors for controlled
delivery of these two messenger molecules to biological targets has grown over
the years and the market for such drugs is expanding at a fast rate. Inorganic
and bioinorganic chemists have already contributed significantly in this area. It
is expected that they will play an important role in the future design and
development of these drugs. |
| Page(s): | 99-107 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0975(Online); 0376-4710(Print) |
| Source: | IJC-A Vol.51A(01-02) [January-February 2012]
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