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IJC-A Vol.51A(01-02) [January-February 2012] >


Title: NO- and CO-donors: An emerging class of pharmaceuticals in current medicine
Authors: Mascharak, Pradip K
Keywords: Nitric oxide
Carbon monoxide
NO-drugs
CORM
Heme oxygenase
Nitrosyl compounds
Carbonyl compounds
Signal transduction
Cytoprotective activity
Issue Date: Jan-2012
Publisher: NISCAIR-CSIR, India
Abstract: In recent years, two small diatomic molecules namely, nitric oxide (NO) and carbon monoxide (CO) have been shown to play key roles in human physiology. Depending on their concentration (in the nano-to-micro molar range), these two molecules exhibit distinct physiological or pathological effects. Several exogenous NO-donors have found use as medication for blood pressure control and as anti-infective agents. CO-donating compounds have shown promises in controlling tissue damage. Demand for new and efficient NO- and CO-donors for controlled delivery of these two messenger molecules to biological targets has grown over the years and the market for such drugs is expanding at a fast rate. Inorganic and bioinorganic chemists have already contributed significantly in this area. It is expected that they will play an important role in the future design and development of these drugs.
Page(s): 99-107
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0975(Online); 0376-4710(Print)
Source:IJC-A Vol.51A(01-02) [January-February 2012]

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