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Title: NO- and CO-donors: An emerging class of pharmaceuticals in current medicine
Authors: Mascharak, Pradip K
Keywords: Nitric oxide;Carbon monoxide;NO-drugs;CORM;Heme oxygenase;Nitrosyl compounds;Carbonyl compounds;Signal transduction;Cytoprotective activity
Issue Date: Jan-2012
Publisher: NISCAIR-CSIR, India
Abstract: In recent years, two small diatomic molecules namely, nitric oxide (NO) and carbon monoxide (CO) have been shown to play key roles in human physiology. Depending on their concentration (in the nano-to-micro molar range), these two molecules exhibit distinct physiological or pathological effects. Several exogenous NO-donors have found use as medication for blood pressure control and as anti-infective agents. CO-donating compounds have shown promises in controlling tissue damage. Demand for new and efficient NO- and CO-donors for controlled delivery of these two messenger molecules to biological targets has grown over the years and the market for such drugs is expanding at a fast rate. Inorganic and bioinorganic chemists have already contributed significantly in this area. It is expected that they will play an important role in the future design and development of these drugs.
Page(s): 99-107
ISSN: 0975-0975(Online); 0376-4710(Print)
Appears in Collections:IJC-A Vol.51A(01-02) [January-February 2012]

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