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Title: Hepatoprotective effect of Barringtonia acutangula Linn. leaves on carbon tetrachloride-induced acute liver damage in rats
Authors: Mishra, S
Sahoo, S
Rout, K K
Nayak, S K
Mishra, S K
Panda, P K
Keywords: Barringtonia acutangula;Carbon tetrachloride;Explant culture;Hepatoprotective activity;Liver Damage;Silymarin
Issue Date: Dec-2011
Publisher: NISCAIR-CSIR, India
IPC Code: Int. cl. (2011.01)—A61K 36/00
Abstract: Barringtonia acutangula Linn. (Barringtoniaceae) is widely distributed throughout India, Southeast Asia, Australia, and Africa. It is used in various indigenous systems of medicine against several diseases and almost every part of the plant has diverse pharmacological properties. The present investigation includes a detailed in vitro and in vivo hepatoprotective activity study of the methanol extract of B. acutangula (BA) leaves on carbon tetrachloride (CCl4) with liquid paraffin (1:1) induced hepatic injury in rats. The methanol extract of BA showed significant (P<0.001) hepatoprotective activity at a dose of 3.3 mg/mL and 250 mg/kg when screened in vitro and in vivo, respectively. An optimized High Performance Thin Layer Chromatographic (HPTLC) fingerprint pattern has been also developed at 254 nm for the identification and quality assessment of raw leaves of (BA).
Page(s): 515-519
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.2(4) [December 2011]

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