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Title: <span style="font-size:13.0pt; mso-bidi-font-size:15.0pt">Hepatoprotective effect of <i style="mso-bidi-font-style: normal">Barringtonia acutangula </i>Linn.<i style="mso-bidi-font-style:normal"> </i>leaves<span style="mso-bidi-font-weight:bold"> on carbon tetrachloride-induced acute liver damage in rats </span></span>
Authors: Mishra, S
Sahoo, S
Rout, K K
Nayak, S K
Mishra, S K
Panda, P K
Keywords: <i style="mso-bidi-font-style:normal"><span style="font-size:11.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Mangal; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:HI" lang="EN-GB">Barringtonia acutangula</span></i>
Carbon tetrachloride
Explant culture
Hepatoprotective activity
Liver Damage
Issue Date: Dec-2011
Publisher: NISCAIR-CSIR, India
Series/Report no.: Int. cl. (2011.01)—A61K 36/00
Abstract: <i style="mso-bidi-font-style: normal">Barringtonia acutangula</i> Linn. (Barringtoniaceae) is widely distributed throughout India, Southeast Asia, Australia, and Africa.<b style="mso-bidi-font-weight: normal"> </b>It is used in various indigenous systems of medicine against several diseases and almost every part of the plant has diverse pharmacological properties. The present investigation includes a detailed <i style="mso-bidi-font-style: normal">in vitro</i> and <i style="mso-bidi-font-style:normal">in vivo</i> hepatoprotective activity study of the methanol extract of <i style="mso-bidi-font-style: normal">B. acutangula</i> (BA) leaves on carbon tetrachloride (CCl<sub>4</sub>) with liquid paraffin (1:1) induced hepatic injury in rats. The methanol extract of BA showed significant (<i style="mso-bidi-font-style:normal">P</i>&lt;0.001) hepatoprotective activity at a dose of 3.3 mg/mL and 250 mg/kg when screened <i style="mso-bidi-font-style:normal">in vitro</i> and <i style="mso-bidi-font-style:normal">in vivo,</i> respectively. An optimized High Performance Thin Layer Chromatographic (HPTLC) fingerprint pattern has been also developed at 254 nm for the identification and quality assessment of raw leaves of (BA).
Description: 515-519
ISSN: 0976-0512 (Online); 0976-0504 (Print)
Appears in Collections:IJNPR Vol.2(4) [December 2011]

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