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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Natural Products and Resources (IJNPR)
[Formerly Natural Product Radiance (NPR)] >
IJNPR Vol.2 [2011] >
IJNPR Vol.2(4) [December 2011] >
| Title: | Molluscicidal and ovicidal activity of euphorginol against two harmful freshwater gastropods |
| Authors: | Chauhan, Saroj
Singh, Ajay |
| Keywords: | Euphorbia tirucalli
Euphorginol
Fascioliasis
Flukes
Gastropods
Indoplanorbis exustus
Lymnaea acuminata
Molluscicidal
Ovicidal
Snails |
| Issue Date: | Dec-2011 |
| Publisher: | NISCAIR-CSIR, India |
| IPC Code: | Int. cl. (2011.01)—A61K 36/47, A61K 129/00, A01P 9/00 |
| Abstract: | Two freshwater gastropods Lymnaea acuminata and Indoplanorbis exustus are the intermediate host of Fasciola hepatica, which causes endemic
fascioliasis disease in cattle and livestock and thus cause immense harm to man
and domestic animals in northern part of India. Thousands of the chemicals
used for controlling these snails cause serious environmental pollution. The
present investigation deals with molluscicidal potential of active compound euphorginol isolated from the stem
bark of a plant Euphorbia tirucalli
Linn. against the above harmful freshwater snails in laboratory as well as in
pond. The toxicity of euphorginol was time as well as dose dependent and there
was a significant negative correlation between LC values and exposure periods.
Thus, the LC50 values of euphorginol was decreased from 1.64 mg/l
(24h) >1.32 mg/l (48h) >0.71 mg/l (72h) >0.46 mg/l (96h) in case of L. acuminata and from 1.91 mg/l (24h)
>1.78 mg/l (48h) >0.88 mg/l (72h) >0.56 mg/l (96h) in the case of I. exustus in laboratory. Similar pattern
of toxicity of euphorginol was found in the pond against both the snails but
toxicity of euphorginol was reduced about four times in pond than laboratory. The sub lethal doses (20% and 40% of 24h LC50)
of euphorginol were exposed to the eggs of both snails and effect was observed
up to 28 days to assess its ovicidal activity under laboratory condition. It
was observed that sub lethal doses of euphorginol significantly reduced the
hatchability of both the snails and maximum reduction was found at the higher
doses. It also reduced the survivability of hatchlings to zero percent in the
case of L. acuminata only after 21
days of hatching than control group. The LC90 (24h)
doses of euphorginol against snails have no apparent killing in non
target organism i.e. fish Channa puctatus
in the treatment of mixed population of snails and fish which shares the
habitat of
these snails. Thus, the active compound euphorginol is toxic against
both the snails and can be helpful in management of fascioliasis eco-friendly.
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| Page(s): | 452-457 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0976-0512 (Online); 0976-0504 (Print) |
| Source: | IJNPR Vol.2(4) [December 2011]
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