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|Title:||Molluscicidal and ovicidal activity of euphorginol against two harmful freshwater gastropods|
|Series/Report no.:||Int. cl. (2011.01)—A61K 36/47, A61K 129/00, A01P 9/00|
|Abstract:||Two freshwater gastropods Lymnaea acuminata and Indoplanorbis exustus are the intermediate host of Fasciola hepatica, which causes endemic fascioliasis disease in cattle and livestock and thus cause immense harm to man and domestic animals in northern part of India. Thousands of the chemicals used for controlling these snails cause serious environmental pollution. The present investigation deals with molluscicidal potential of active compound euphorginol isolated from the stem bark of a plant Euphorbia tirucalli Linn. against the above harmful freshwater snails in laboratory as well as in pond. The toxicity of euphorginol was time as well as dose dependent and there was a significant negative correlation between LC values and exposure periods. Thus, the LC50 values of euphorginol was decreased from 1.64 mg/l (24h) >1.32 mg/l (48h) >0.71 mg/l (72h) >0.46 mg/l (96h) in case of L. acuminata and from 1.91 mg/l (24h) >1.78 mg/l (48h) >0.88 mg/l (72h) >0.56 mg/l (96h) in the case of I. exustus in laboratory. Similar pattern of toxicity of euphorginol was found in the pond against both the snails but toxicity of euphorginol was reduced about four times in pond than laboratory. The sub lethal doses (20% and 40% of 24h LC50) of euphorginol were exposed to the eggs of both snails and effect was observed up to 28 days to assess its ovicidal activity under laboratory condition. It was observed that sub lethal doses of euphorginol significantly reduced the hatchability of both the snails and maximum reduction was found at the higher doses. It also reduced the survivability of hatchlings to zero percent in the case of L. acuminata only after 21 days of hatching than control group. The LC90 (24h) doses of euphorginol against snails have no apparent killing in non target organism i.e. fish Channa puctatus in the treatment of mixed population of snails and fish which shares the habitat of these snails. Thus, the active compound euphorginol is toxic against both the snails and can be helpful in management of fascioliasis eco-friendly.|
|ISSN:||0976-0512 (Online); 0976-0504 (Print)|
|Appears in Collections:||IJNPR Vol.2(4) [December 2011]|
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