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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(01) [January 2012] >
| Title: | Staurosporine induced poly (ADP-ribose) polymerase independent cell death in Dictyostelium discoideum |
| Authors: | Mir, Hina
Rajawat, Jyotika
Begum, Rasheedunnisa |
| Keywords: | Apoptosis inducing factor
Benzamide
Cathepsin
Pepstatin
Staurosporine |
| Issue Date: | Jan-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | In the present study D. discoideum has been used as a model organism to understand the
role of poly (ADP-ribose) polymerase (PARP) in caspase independent paraptotic cell
death pathways. D. discoideum lacks
caspases and Bcl-2 family proteins; nevertheless it has 9 potential genes for
PARP. PARP has been known to get activated in various cell death associated
diseases. In this study kinetics of cell death induced by staurosporine (STS),
a bacterial alkaloid, was established to unravel the role of PARP. It was found
that STS induced cell death in D.
discoideum did not involve PARP activation, however it involved cathepsin
D. Results indicated that an alternative mechanism may be existing in D. discoideum that lacks Bcl-2 family proteins for STS induced cell death that evades
Bax involvement. |
| Page(s): | 80-86 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(01) [January 2012]
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