Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/13312
Title: Antinociceptive activity of Sesbania sesban (Linn) wood extracts, a preliminary study
Authors: Nirmal, S A
Bairagi, J H
Patil, A N
Pal, S C
Upasani, C D
Mandal, S C
Keywords: Hot plate test
Naloxone
Sesbania sesban
Writhing test
Issue Date: Jan-2012
Publisher: NISCAIR-CSIR, India
Abstract: The wood of the plant Sesbania sesban, is reported to have antinociceptive activity. To validate its folk use in the treatment of pain, wood was extracted successively with petroleum ether, chloroform, ethyl acetate, ethanol, and water to produce respective extracts. The extracts (50 and 100 mg/kg, ip) were screened for antinociceptive activity using hot plate test and acetic acid-induced writhing test in mice. Petroleum ether, chloroform, and ethyl acetate extracts showed significant and dose-dependent activity in both the tests. In order to find out the involvement of opioid receptors, effect of naloxone (1 mg/kg, sc) on the action of extracts was checked in hot plate test. Petroleum ether, chloroform, and ethyl acetate extracts showed significant and dose dependant antinociceptive activity. The antinociceptive action of the extracts was blocked by naloxone, suggesting involvement of opioid receptors in the action.
Description: 61-64
URI: http://hdl.handle.net/123456789/13312
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.50(01) [January 2012]

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