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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(01) [January 2012] >
| Title: | Interaction of hydroalcoholic extract of Acorus calamus Linn. with sodium valproate and carbamazepine |
| Authors: | Katyal, Jatinder
Sarangal, Vikas
Gupta, Yogendra Kumar |
| Keywords: | Acorus calamus
Carbamazepine
Pentylenetetrazole-induced seizures
Sodium valproate |
| Issue Date: | Jan-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Anticonvulsant property of Acorus calamus is known. Since
combination therapy can lower the dose of individual drug and dose related
toxicities, in this study, the effect of co-administration of hydroalcoholic
extract of A. calamus (HAEAC) on
conventional antiepileptic drugs (AEDs), sodium valproate and carbamazepine was
determined using pentylenetetrazole -induced seizures model in rats. On
combining the subanticonvulsant doses of HAEAC with sodium valproate and
carbamazepine, greater protection as compared to either drug alone was
observed. This was not related to change in levels of the AEDs. Thus, the
results further substantiate anticonvulsant effect of HAEAC and suggest a
potential for add on therapy with AEDs. |
| Page(s): | 51-55 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(01) [January 2012]
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