Please use this identifier to cite or link to this item:
|Title:||Interaction of hydroalcoholic extract of Acorus calamus Linn. with sodium valproate and carbamazepine|
Gupta, Yogendra Kumar
|Keywords:||Acorus calamus;Carbamazepine;Pentylenetetrazole-induced seizures;Sodium valproate|
|Abstract:||Anticonvulsant property of Acorus calamus is known. Since combination therapy can lower the dose of individual drug and dose related toxicities, in this study, the effect of co-administration of hydroalcoholic extract of A. calamus (HAEAC) on conventional antiepileptic drugs (AEDs), sodium valproate and carbamazepine was determined using pentylenetetrazole -induced seizures model in rats. On combining the subanticonvulsant doses of HAEAC with sodium valproate and carbamazepine, greater protection as compared to either drug alone was observed. This was not related to change in levels of the AEDs. Thus, the results further substantiate anticonvulsant effect of HAEAC and suggest a potential for add on therapy with AEDs.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.50(01) [January 2012]|
Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.