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Title: Interaction of hydroalcoholic extract of Acorus calamus Linn. with sodium valproate and carbamazepine
Authors: Katyal, Jatinder
Sarangal, Vikas
Gupta, Yogendra Kumar
Keywords: Acorus calamus
Pentylenetetrazole-induced seizures
Sodium valproate
Issue Date: Jan-2012
Publisher: NISCAIR-CSIR, India
Abstract: Anticonvulsant property of Acorus calamus is known. Since combination therapy can lower the dose of individual drug and dose related toxicities, in this study, the effect of co-administration of hydroalcoholic extract of A. calamus (HAEAC) on conventional antiepileptic drugs (AEDs), sodium valproate and carbamazepine was determined using pentylenetetrazole -induced seizures model in rats. On combining the subanticonvulsant doses of HAEAC with sodium valproate and carbamazepine, greater protection as compared to either drug alone was observed. This was not related to change in levels of the AEDs. Thus, the results further substantiate anticonvulsant effect of HAEAC and suggest a potential for add on therapy with AEDs.
Page(s): 51-55
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.50(01) [January 2012]

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