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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(01) [January 2012] >
| Title: | Modulation of intestinal brush border membrane chemical composition during postnatal development in rats : Effect of gestational diabetes |
| Authors: | Sharma, Ruchi
Chauhan, Shailender Singh
Mahmood, Akhtar |
| Keywords: | Brush border membrane composition
Gestational diabetes
Postnatal development
Small intestine |
| Issue Date: | Jan-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | There was a significant increase in fucose
(52%), total hexoses (16%) and hexosamine (56%) except sialic acid, which was
reduced (77%) in the microvillus membrane of infants born to rat mothers made
diabetic by injecting alloxan on day 3 of gestation. Expressed on the protein
basis there were a significant increase in membrane, triglyceride, total cholesterol,
and phospholipids content of brush border in pups from diabetic group between
5-45 days of postnatal age. Intestinal morphology in diabetic group showed,
regression of tubular glands, distorted cellular organization of mucosal cells,
reduction in the mucosal cell height and number of secretory goblet cells.
These findings suggest that the gestational diabetes affects the sugar and
lipid composition of the intestinal brush border membrane in rats during early
stages of the postnatal development, which may be associated with compromised
tissue functions later in life. |
| Page(s): | 45-50 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(01) [January 2012]
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