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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(01) [January 2012] >
| Title: | Crosstalk between RXR, LXR and VDR within blood mononuclear cellular model |
| Authors: | Dave, Vivek P
Kaul, Deepak
Sharma, Monika |
| Keywords: | Nuclear receptors
LXR
RXR
VDR |
| Issue Date: | Jan-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | An accumulation of data from in vitro to in vivo
model system has established a pivotal role of three crucial ligand activated
nuclear receptors RXR, LXR-α and VDR for their ability to regulate an array of
genes involved in regulation of fundamental cellular processes to
patho-physiological situations. Keeping in view RXR as a common heterodimeric
partner for LXR-α and VDR, the present study was designed to dissect the
interrelationship between these three nuclear receptors in peripheral blood
mononuclear cellular model. The present study revealed that all the three
nuclear receptors displayed auto regulation in response to their specific
ligands; Both LXR-α and VDR regulated the expression of their heterodimeric
partner RXR; and VDR was regulated by LXR-α through its ability to modulate
SREBP response element present in the promoter region of VDR gene. Based on
these findings, the role of these nuclear receptors could be better understood
in various nuclear receptor mediated pathological processes. |
| Page(s): | 35-40 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(01) [January 2012]
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