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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.50 [2012] >
IJEB Vol.50(01) [January 2012] >
| Title: | Sodium butyrate modulates pRb phosphorylation and induces cell death in human vestibular schwannomas in vitro |
| Authors: | Mitra, Rohan
Devi, B Indira
Gope, Mohan L
Subbakrishna, D K
Gope, Rajalakshmi |
| Keywords: | Apoptosis
Cell death
Human vestibular schwannoma
pRb phosphorylation
Sodium butyrate |
| Issue Date: | Jan-2012 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | In the present study,
effect of Na-Bu on the pRb phosphorylation was analysed in the primary cultures
of 12 VS tumors. Primary cultures of VS tumors were established from the fresh
tumor tissues removed surgically and were treated with
Na-Bu. Na-Bu treatment for 48 h led to morphological changes and apoptotic cell
death in VS tumor cells. Na-Bu treatment decreased level of total pRb and
phosphorylated form of pRb and caused specific dephosphorylation at Ser 249/Thr
252 and Ser 567. In the untreated and Na-Bu treated cells (when present), pRb
was localised in the nucleus. Moreover, in Na-Bu treated cells the nucleus
appeared highly condensed as compared to untreated cells. Results of the
present study indicated that Na-Bu treatment modulated pRb phosphorylation
status and caused apoptotic cell death in VS tumors.
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| Page(s): | 19-27 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.50(01) [January 2012]
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