Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/132
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dc.contributor.authorHamid, Nowsheen-
dc.contributor.authorJain, S K-
dc.date.accessioned2008-02-22T09:28:18Z-
dc.date.available2008-02-22T09:28:18Z-
dc.date.issued2007-10-
dc.identifier.issn0301-1208-
dc.identifier.urihttp://hdl.handle.net/123456789/132-
dc.description320-330en_US
dc.description.abstractSalmonella, a facultative intracellular Gram-negative bacterium infects a wide range of hosts causing several gastrointestinal diseases and enteric fever in humans and certain animal species. Typhoid caused by Salmonella typhi remains a major health concern in India and worldwide. Also, with emergence of multidrug resistant strains, Salmonella has acquired increased virulence, communicability and survivability, resulting in increased morbidity and mortality. Though a number of vaccines for typhoid are available against S. typhi (or also against S. typhimurium), these have certain undesirable side effects and the search for new immunogens suitable for vaccine formulation is still continuing. The immune response to primary Salmonella infection involves both humoral and cell-mediated responses. The protective immunity against Salmonella depends on host- parasite interaction, however; the detailed mechanism of virulence, innate resistance and susceptibility of host remains unclear. This review focuses on the molecular, immunological and cellular mechanisms of pathogenesis of Salmonella infection to provide an insight to counteract bacterial infections and allow a better understanding of its clinical manifestations. It also reviews better technological possibilities combined with increased knowledge in related fields such as immunology and molecular biology and allow for new vaccination strategies. Some new approaches such as subunit and nucleic acid vaccines and recombinant antigen which are becoming increasingly important for the development of potential vaccines have also been discussed. A significant progress has been made in our understanding of Salmonella pathogenesis. Despite these efforts, however, many challenges exist, especially for investigators who aim to understand how the pathogenic mechanisms operating in vitro apply to in vivo model systems. However, unyielding work and collaborations between Salmonella researchers and clinicians worldwide have made significant contributions to understanding the interaction between virulence determinants and immunity required to stop the spread of this pathogen.en_US
dc.language.isoen_USen_US
dc.publisherCSIRen_US
dc.sourceIJBB Vol.44(5) [October 2007]en_US
dc.subjectOuter membrane proteinsen_US
dc.subjectPathogenesisen_US
dc.subjectSalmonellaen_US
dc.subjectTyphoiden_US
dc.subjectVaccineen_US
dc.subjectVirulence.en_US
dc.titleImmunological, Cellular and Molecular Events in Typhoid Feveren_US
dc.typeArticleen_US
Appears in Collections:IJBB Vol.44(5) [October 2007]

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