Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/13254
Title: <i style="mso-bidi-font-style:normal"><span style="font-size:11.0pt;mso-bidi-font-size:10.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman";mso-font-kerning:18.0pt;mso-ansi-language: EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">DAZL </span></i><span style="font-size:11.0pt;mso-bidi-font-size:10.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman";mso-font-kerning:18.0pt;mso-ansi-language: EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">260A>G and <i>MTHFR </i>677C>T variants in sperm DNA of infertile Indian men</span>
Authors: Kumar, Kishlay
Venkatesh, S
Sharma, P R
Tiwari, P K
Dada, Rima
Keywords: Male infertility
<i style="mso-bidi-font-style:normal"><span style="font-size:9.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language: EN-US;mso-bidi-language:AR-SA" lang="EN-GB">DAZL</span></i><span style="font-size:9.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language:EN-US; mso-bidi-language:AR-SA" lang="EN-GB"> 260A>G</span>
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mso-bidi-font-size:10.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Mangal; mso-bidi-theme-font:minor-bidi;} </style> <![endif]--><i style="mso-bidi-font-style:normal"><span style="font-size:9.0pt;font-family:"Times New Roman","serif"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language: EN-US;mso-bidi-language:AR-SA" lang="EN-GB">MTHFR</span></i><span style="font-size:9.0pt;font-family:"Times New Roman","serif";mso-fareast-font-family: "Times New Roman";mso-ansi-language:EN-GB;mso-fareast-language:EN-US; mso-bidi-language:AR-SA" lang="EN-GB"> 677C>T</span>
Oligozoospermic
Single nucleotide polymorphism
Issue Date: Dec-2011
Publisher: NISCAIR-CSIR, India
Abstract: <i><span style="font-size:11.0pt; mso-bidi-font-size:10.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="" lang="EN-GB">DAZL</span></i><span style="font-size:11.0pt; mso-bidi-font-size:10.0pt;font-family:" times="" new="" roman","serif";mso-fareast-font-family:="" "times="" roman";mso-ansi-language:en-gb;mso-fareast-language:en-us;="" mso-bidi-language:ar-sa"="" lang="EN-GB"> (deleted in azoospermia-like)<i>&nbsp;</i>260A&gt;G and <i>MTHFR</i> (methylene tetrahydrofolate reductase<i>) </i>677C&gt;T are two important autosomal variants associated with impaired spermatogenesis. In this study, we investigated <i style="mso-bidi-font-style:normal">DAZL</i> 260A&gt;G and <i style="mso-bidi-font-style:normal">MTHFR</i> 677C&gt;T variants in sperm DNA and their frequency in oligozoospermic infertile men of Indian origin. The study on sperm DNA was performed, since it is more prone to oxidative stress-induced damage and mutation. One hundred oligozoopsermic infertile men having normal chromosomal complement with intact Y chromosome and 100 age- and ethnically-matched fertile controls were investigated for these variants in their sperm genome. Spermatozoa were separated by gradient centrifugation and DNA was isolated and analyzed for the single nucleotide polymorphisms (SNPs) by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). The results showed no significant differences in the frequency of <i>DAZL </i><span style="mso-bidi-font-style: italic">AG (P = 0.58) and <i style="mso-bidi-font-style:normal">MTHFR<span style="mso-bidi-font-style: italic"> </span></i>CT (P = 0.44) between oligozoospermic infertile men and controls. However, 8% (8/100) oligozoospermic infertile men harbored both the variants and showed significantly (P&lt;0.0001) lower sperm count (3.28 ± 1.1 vs 12.50 ± 4.09) compared to infertile men with either of the single variant. None of the fertile controls showed the presence of the both variants. In conclusion, the combined effect of both <i style="mso-bidi-font-style:normal">DAZL</i> 260A&gt;G and <i style="mso-bidi-font-style: normal">MTHFR</i> 677C&gt;T variants may have role in compromised sperm count. However, further studies are required to find the pathological role of these combined variants in male infertility.</span></span>
Description: 422-426
URI: http://hdl.handle.net/123456789/13254
ISSN: 0975-0959 (Online); 0301-1208 (Print)
Appears in Collections:IJBB Vol.48(6) [December 2011]

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