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Title: Preparation and evaluation of inclusion complexes of carvedilol
Authors: Bhutani, Saurabh
Hiremath, S N
Swamy, P V
Raju, S A
Keywords: Carvedilol
Hydroxypropyl β-cyclodextrin
Kneading method
Physical mixture
Issue Date: Oct-2007
Publisher: CSIR
Abstract: Inclusion behaviour of hydroxypropyl β-cyclodextrin (HPβ-CD) was studied towards carvedilol, an antihypertensive agent, in order to develop a new oral dosage form with enhanced dissolution rate and bioavailability, following cyclodextrin complexation. Formation of inclusion complexes with HPβ-CD in the solid state was confirmed by DSC and FTIR and comparative studies on in-vitro dissolution were carried out. Phase solubility studies indicated formation of 1:1 M complex for HPβ-CD. Apparent stability constant (Kc) was found to be 582.78 M⁻¹ for HPβ-CD complexes. DSC studies indicated formation of solid inclusion complexes of carvedilol–HPβ-CD at 1:2 M ratio prepared by kneading method. Solid complexes of carvedilol-HPβ-CD at 1:2 M prepared by physical and kneading method exhibited higher dissolution rate and dissolution efficiency values than the pure drug and other complexes.
Page(s): 830-834
ISSN: 0022-4456
Source:JSIR Vol.66(10) [October 2007]

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