19-Jun-2013
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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
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Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(12) December 2011] >
| Title: | Synthesis and antimicrobial activity of novel spiro-isoxazolyl oxazolidin-4-one-[5,51]-1,2,4-oxadiazolines and thiazolidin-4-one-[5,51]-1,2,4-oxadiazolines |
| Authors: | Rajanarendar, E
Reddy, A Siva Rami
Reddy, K Govardhan
Raju, S |
| Keywords: | Spiro-isoxazolyl oxazolidin-4-one[5,51]-1,2,4-oxadiazolines
Spiro isoxazolyl thiazolidin-4-one[5,51]-1,2,4-oxadiazolines
Cycloaddition
Antimicrobial activity |
| Issue Date: | Dec-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The synthesis of novel isoxazolyl
1,6-dioxa-2,4,9-triazaspiro[5,51]-non-2-ene-8-ones 4 and isoxazolyl 1-oxa-6-thia-2,4,9-triazaspiro[5,51]-non-2-ene-8-ones
6 analogs is described. Reaction of N-1-(3,5-dimethyl-4-isoxazolyl)-2-chloroacetamide
2 with arylisocyanates yields
3-(3,5-dimethyl-4-isoxazolyl)-2-arylimino-1,3-oxazolan-4-ones 3. Cycloaddition of 3 with benzonitrile oxides furnishes
novel spiro isoxazolyl oxazolidin-4-one[5,51]-1,2,4-oxadiazolines 4. Reaction of 2 with arylisothiocyanates affords
3-(3,5-dimethyl-4-isoxazolyl)-2-arylimino-1,3-thiazolan-4ones 5. Cycloaddition of 5 with benzonitrile oxides yields novel spiro isoxazolyl
thiazolidin-4-one[5,51]-1,2,4-oxadiazolines 6. All the new products have been characterized by elemental
analyses, IR, 1H NMR and mass spectral studies. Compounds 4 and 6 have been screened for their antimicrobial activity. |
| Page(s): | 1800-1806 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(12) December 2011]
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