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Title: Microwave assisted synthesis of some novel pyrazole substituted benzimidazoles and evaluation of their biological activities
Authors: Kalirajan, R
Rathore, Leela
Jubie, S
Gowramma, B
Gomathy, S
Sankar, S
Keywords: Benzimidazoles
Microwave irradiation
Issue Date: Dec-2011
Publisher: NISCAIR-CSIR, India
Abstract: <span style="font-size:12.0pt;font-family: " times="" new="" roman","serif";mso-fareast-font-family:"times="" roman";mso-ansi-language:="" en-gb;mso-fareast-language:en-us;mso-bidi-language:ar-sa"="" lang="EN-GB">A series of novel and significant compounds containing pyrazole substituted benzimidazoles <b style="mso-bidi-font-weight:normal">4a-h </b>and<b style="mso-bidi-font-weight: normal"> 5a-h</b> have been synthesized from <i style="mso-bidi-font-style: normal">o</i>-phenylenediamine under microwave irradiation. The structures of the newly synthesized compounds have been confirmed on the basis of elemental analysis and spectral data. Some of the synthesized compounds <b style="mso-bidi-font-weight:normal">4b, 4h, 5d, 5f</b> exhibit significant antibacterial activity. The compounds <b style="mso-bidi-font-weight:normal">5b, 5f</b> exhibit good antifungal activity. Compounds <b style="mso-bidi-font-weight: normal">5a</b> and <b style="mso-bidi-font-weight:normal">5b </b>have shown good anticancer activity and the compound <b style="mso-bidi-font-weight:normal">4a</b> exhibits significant anti tubercular activity.</span>
Description: 1794-1799
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(12) December 2011]

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