Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/13101
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dc.contributor.authorSurendran, S-
dc.contributor.authorEswaran, M Bavani-
dc.contributor.authorVijayakumar, M-
dc.contributor.authorRao, Ch V-
dc.date.accessioned2011-11-30T09:38:35Z-
dc.date.available2011-11-30T09:38:35Z-
dc.date.issued2011-12-
dc.identifier.issn0975-1009 (Online); 0019-5189 (Print)-
dc.identifier.urihttp://hdl.handle.net/123456789/13101-
dc.description939-945en_US
dc.description.abstractAdministration of hydroalcoholic extract of Cissampelos pareira roots (CPRE) and standard drug silymarin in rats showed significant hepatoprotective action against CCl4 induced hepatotoxicity. Elevated serum marker enzymes of AST, ALT, ALP and serum bilirubin were significantly reduced to near normal level in CPRE treated rats. Lipid peroxidation level was decreased significantly in CPRE 100, 200, 400 mg/kg doses treatment groups. In case of antioxidant enzymes SOD, catalase levels were increased significantly after CPRE 200, 400 mg/kg doses, similarly it increased the enzyme levels of GST, GPx, and GSH. CPRE 200, 400 mg/kg decreased cholesterol level, and increased triglyceride level. In vitro hepatoprotective activity of the extract was evaluated at 20, 40, 60, 80 and 100 µg/ml concentration against CCl4 (1%) induced toxicity in freshly isolated rat hepatocytes. HepG2 cells showed significant dose dependent increase in percentage viability at the doses 20, 40, 60, 80 and 100 µg/ml of CPRE compared to CCl4 exposed HepG2 cells. Results of this study strongly demonstrate Cissampelos pariera having good hepatoprotective potential.en_US
dc.language.isoen_USen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.rights CC Attribution-Noncommercial-No Derivative Works 2.5 Indiaen_US
dc.sourceIJEB Vol.49(12) [December 2011]en_US
dc.subjectAntioxidant enzymesen_US
dc.subjectCarbon tetrachlorideen_US
dc.subjectCissampelos pareiraen_US
dc.subjectHepatoprotectiveen_US
dc.subjectHepG2 cellsen_US
dc.titleIn vitro and in vivo hepatoprotective activity of Cissampelos pareira against carbon-tetrachloride induced hepatic damageen_US
dc.typeArticleen_US
Appears in Collections:IJEB Vol.49(12) [December 2011]

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