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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(12) [December 2011] >
| Title: | In vitro and in vivo hepatoprotective activity of Cissampelos pareira against carbon-tetrachloride induced hepatic damage |
| Authors: | Surendran, S
Eswaran, M Bavani
Vijayakumar, M
Rao, Ch V |
| Keywords: | Antioxidant enzymes
Carbon tetrachloride
Cissampelos pareira
Hepatoprotective
HepG2 cells |
| Issue Date: | Dec-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Administration of hydroalcoholic extract of Cissampelos pareira roots (CPRE) and standard drug silymarin in rats showed significant
hepatoprotective action against CCl4 induced hepatotoxicity. Elevated serum
marker enzymes of AST, ALT, ALP and serum
bilirubin were significantly reduced to near normal level in CPRE treated rats.
Lipid peroxidation level was
decreased significantly in CPRE 100, 200, 400 mg/kg doses treatment groups. In case of antioxidant enzymes SOD, catalase levels were increased significantly after CPRE 200, 400 mg/kg doses, similarly it increased the enzyme levels of
GST, GPx, and GSH. CPRE 200, 400 mg/kg decreased cholesterol level, and
increased triglyceride level. In vitro hepatoprotective activity
of the extract was evaluated at 20, 40, 60, 80 and 100 µg/ml concentration
against CCl4 (1%) induced toxicity in freshly isolated rat
hepatocytes. HepG2 cells showed significant dose
dependent increase in percentage viability at the doses 20, 40, 60, 80 and 100 µg/ml
of CPRE compared to CCl4 exposed HepG2 cells. Results of this study
strongly demonstrate Cissampelos pariera having good
hepatoprotective potential. |
| Page(s): | 939-945 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(12) [December 2011]
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