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Title: <i>In vitro</i> and <i>in vivo </i>hepatoprotective activity of <i>Cissampelos pareira</i> against carbon-tetrachloride induced hepatic damage
Authors: Surendran, S
Eswaran, M Bavani
Vijayakumar, M
Rao, Ch V
Keywords: Antioxidant enzymes
Carbon tetrachloride
<i>Cissampelos pareira</i>
HepG2 cells
Issue Date: Dec-2011
Publisher: NISCAIR-CSIR, India
Abstract: Administration of hydroalcoholic extract of <i>Cissampelos pareira</i> roots (CPRE) and standard drug silymarin in rats showed significant hepatoprotective action against CCl<sub>4 </sub>induced hepatotoxicity. Elevated serum marker enzymes of AST, ALT, ALP and serum bilirubin were significantly reduced to near normal level in CPRE treated rats. Lipid peroxidation level was decreased significantly in CPRE 100, 200, 400 mg/kg doses treatment groups. In case of antioxidant enzymes SOD, catalase levels were increased significantly after CPRE<i> </i>200, 400 mg/kg doses, similarly it increased the enzyme levels of GST, GPx, and GSH. CPRE 200, 400 mg/kg decreased cholesterol level, and increased triglyceride level.<i> In vitro</i> hepatoprotective activity of the extract was evaluated at 20, 40, 60, 80 and 100 µg/ml concentration against CCl<sub>4</sub> (1%) induced toxicity in freshly isolated rat hepatocytes. HepG2 cells showed significant dose dependent increase in percentage viability at the doses 20, 40, 60, 80 and 100 µg/ml of CPRE compared to CCl<sub>4</sub> exposed HepG2 cells. Results of this study strongly demonstrate <i>Cissampelos</i><i> pariera</i> having good hepatoprotective potential.
Description: 939-945
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(12) [December 2011]

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