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Title: Antiinflammatory, analgesic and antipyretic activities of <i style="">Linum usitatissimum</i> L. (flaxseed/linseed) fixed oil
Authors: Kaithwas, Gaurav
Mukherjee, Alok
Chaurasia, A K
Majumdar, Dipak K
Keywords: Antibradykinin
Arachidonic acid
<img src='' border=0>-Linolenic acid
Issue Date: Dec-2011
Publisher: NISCAIR-CSIR, India
Abstract: The fixed oil of <i>L. </i><i style="">usitatissimum</i> (flaxseed/linseed) inhibited PGE<sub>2</sub>-, leukotriene-, histamine- and bradykinin-induced inflammation. The oil also inhibited arachidonic acid-induced inflammation, suggesting its capacity to inhibit both cyclooxygenase and lipoxygenase pathways of arachidonate metabolism. In tail immersion model, the oil raised the pain threshold to a lesser extent than morphine but showed excellent peripherally acting, analgesic activity comparable to aspirin, against acetic acid-induced writhing in mouse. In typhoid paratyphoid A/B vaccine-induced pyrexia, the oil showed antipyretic activity comparable to aspirin. <span style="color: rgb(51, 51, 51);">The oil contains 57.38% <img src='' border=0>-linolenic acid. Dual inhibition of arachidonic acid metabolism, antihistaminic and antibradykinin activities of the oil could account for the biological activity and the active principle could be <img src='' border=0>-linolenic acid an omega-3 (18:3, n-3) fatty acid. </span>
Description: 932-938
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(12) [December 2011]

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