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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(12) [December 2011] >
| Title: | Antiinflammatory, analgesic and antipyretic activities of Linum usitatissimum L. (flaxseed/linseed) fixed oil |
| Authors: | Kaithwas, Gaurav
Mukherjee, Alok
Chaurasia, A K
Majumdar, Dipak K |
| Keywords: | Antibradykinin
Antihistaminic
Arachidonic acid
Dual-inhibitor
 -Linolenic acid |
| Issue Date: | Dec-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | The fixed oil of L. usitatissimum (flaxseed/linseed)
inhibited PGE2-, leukotriene-, histamine- and bradykinin-induced
inflammation. The oil also inhibited arachidonic acid-induced inflammation,
suggesting its capacity to inhibit both cyclooxygenase and lipoxygenase
pathways of arachidonate metabolism. In tail immersion model, the oil raised
the pain threshold to a lesser extent than morphine but showed excellent peripherally
acting, analgesic activity comparable to aspirin, against acetic acid-induced
writhing in mouse. In typhoid paratyphoid A/B vaccine-induced pyrexia, the oil showed antipyretic activity comparable to aspirin. The oil
contains 57.38% -linolenic acid. Dual
inhibition of arachidonic acid metabolism, antihistaminic and antibradykinin
activities of the oil could account for the biological activity and the active
principle could be -linolenic acid an omega-3 (18:3, n-3) fatty acid.
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| Page(s): | 932-938 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(12) [December 2011]
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