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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(12) [December 2011] >
| Title: | Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid |
| Authors: | Toliopoulos, Ioannis K.
Simos, Yannis V.
Daskalou, Telemachos A.
Verginadis, Ioannis I.
Evangelou, Angelos M.
Karkabounas, Spyros C. |
| Keywords: | Ascorbic acid
Natural killer cells
Platelet glycoprotein GpIIb-IIIa complex
Thromboxane B2 |
| Issue Date: | Dec-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Platelets aggregation around migrating tumor
cells offers protection against the cytotoxic activity of the natural killers
cells (NKC). The ascorbic acid in 3X10-3Μ
concentration completely inhibited platelet aggregation, decreased thromboxane
B2 levels, and inhibited the expression of platelet membranic
receptor GpIIb/IIIa in non stimulated platelets, and increased the NKC
cytotoxicity in an average rate of 105, 61, and 285% in the NKC/targets cells
ratios 12.5:1, 25:1 and 50:1 respectively. The results suggest the role of
ascorbic acid in increasing the susceptibility of tumor cells to NKC; the
ascorbic acid could be used as part of a multidrug therapy to treat diseases
which up to now have been treated only through chemotherapy. |
| Page(s): | 904-908 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(12) [December 2011]
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