NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(12) [December 2011] >


Title: Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid
Authors: Toliopoulos, Ioannis K.
Simos, Yannis V.
Daskalou, Telemachos A.
Verginadis, Ioannis I.
Evangelou, Angelos M.
Karkabounas, Spyros C.
Keywords: Ascorbic acid
Natural killer cells
Platelet glycoprotein GpIIb-IIIa complex
Thromboxane B2
Issue Date: Dec-2011
Publisher: NISCAIR-CSIR, India
Abstract: Platelets aggregation around migrating tumor cells offers protection against the cytotoxic activity of the natural killers cells (NKC). The ascorbic acid in 3X10-3Μ concentration completely inhibited platelet aggregation, decreased thromboxane B2 levels, and inhibited the expression of platelet membranic receptor GpIIb/IIIa in non stimulated platelets, and increased the NKC cytotoxicity in an average rate of 105, 61, and 285% in the NKC/targets cells ratios 12.5:1, 25:1 and 50:1 respectively. The results suggest the role of ascorbic acid in increasing the susceptibility of tumor cells to NKC; the ascorbic acid could be used as part of a multidrug therapy to treat diseases which up to now have been treated only through chemotherapy.
Page(s): 904-908
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.49(12) [December 2011]

Files in This Item:

File Description SizeFormat
IJEB 49(12) 904-908.pdf97.21 kBAdobe PDFView/Open
 Current Page Visits: 441 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 569920 since 06-Feb-2009  Last updated on 14-Aug-2014Webmaster: nopr@niscair.res.in