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Title: Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid
Authors: Toliopoulos, Ioannis K.
Simos, Yannis V.
Daskalou, Telemachos A.
Verginadis, Ioannis I.
Evangelou, Angelos M.
Karkabounas, Spyros C.
Keywords: Ascorbic acid;Natural killer cells;Platelet glycoprotein GpIIb-IIIa complex;Thromboxane B2
Issue Date: Dec-2011
Publisher: NISCAIR-CSIR, India
Abstract: Platelets aggregation around migrating tumor cells offers protection against the cytotoxic activity of the natural killers cells (NKC). The ascorbic acid in 3X10-3Μ concentration completely inhibited platelet aggregation, decreased thromboxane B2 levels, and inhibited the expression of platelet membranic receptor GpIIb/IIIa in non stimulated platelets, and increased the NKC cytotoxicity in an average rate of 105, 61, and 285% in the NKC/targets cells ratios 12.5:1, 25:1 and 50:1 respectively. The results suggest the role of ascorbic acid in increasing the susceptibility of tumor cells to NKC; the ascorbic acid could be used as part of a multidrug therapy to treat diseases which up to now have been treated only through chemotherapy.
Page(s): 904-908
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(12) [December 2011]

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