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|Title:||Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid|
|Authors:||Toliopoulos, Ioannis K.|
Simos, Yannis V.
Daskalou, Telemachos A.
Verginadis, Ioannis I.
Evangelou, Angelos M.
Karkabounas, Spyros C.
Natural killer cells
Platelet glycoprotein GpIIb-IIIa complex
|Abstract:||Platelets aggregation around migrating tumor cells offers protection against the cytotoxic activity of the natural killers cells (NKC). The ascorbic acid in 3X10<sup>-3</sup>Μ concentration completely inhibited platelet aggregation, decreased thromboxane B<sub>2 </sub>levels, and inhibited the expression of platelet membranic receptor GpIIb/IIIa in non stimulated platelets, and increased the NKC cytotoxicity in an average rate of 105, 61, and 285% in the NKC/targets cells ratios 12.5:1, 25:1 and 50:1 respectively. The results suggest the role of ascorbic acid in increasing the susceptibility of tumor cells to NKC; the ascorbic acid could be used as part of a multidrug therapy to treat diseases which up to now have been treated only through chemotherapy.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.49(12) [December 2011]|
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