NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49  >
IJEB Vol.49(12) [December 2011] >
|Title: ||Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid|
|Authors: ||Toliopoulos, Ioannis K.|
Simos, Yannis V.
Daskalou, Telemachos A.
Verginadis, Ioannis I.
Evangelou, Angelos M.
Karkabounas, Spyros C.
|Keywords: ||Ascorbic acid|
Natural killer cells
Platelet glycoprotein GpIIb-IIIa complex
|Issue Date: ||Dec-2011 |
|Publisher: ||NISCAIR-CSIR, India|
|Abstract: ||Platelets aggregation around migrating tumor
cells offers protection against the cytotoxic activity of the natural killers
cells (NKC). The ascorbic acid in 3X10-3Μ
concentration completely inhibited platelet aggregation, decreased thromboxane
B2 levels, and inhibited the expression of platelet membranic
receptor GpIIb/IIIa in non stimulated platelets, and increased the NKC
cytotoxicity in an average rate of 105, 61, and 285% in the NKC/targets cells
ratios 12.5:1, 25:1 and 50:1 respectively. The results suggest the role of
ascorbic acid in increasing the susceptibility of tumor cells to NKC; the
ascorbic acid could be used as part of a multidrug therapy to treat diseases
which up to now have been treated only through chemotherapy.|
|CC License: || CC Attribution-Noncommercial-No Derivative Works 2.5 India|
|ISSN: ||0975-1009 (Online); 0019-5189 (Print)|
|Source:||IJEB Vol.49(12) [December 2011]|