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NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Geo-Marine Sciences (IJMS) >
IJMS Vol.40 [2011] >
IJMS Vol.40(5) [October 2011] >
| Title: | Free radical scavenging and anti-inflammatory potential of a marine brown alga Turbinaria ornata (Turner) J.Agardh |
| Authors: | Ananthi, S
Gayathri, V
Chandronitha, C
Lakshmisundaram, R
Vasanthi, Hannah R |
| Keywords: | Turbinaria ornata
Seaweed
Free radical scavenging
Antioxidant
Inflammation
Anti-inflammatory |
| Issue Date: | Oct-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | In the
present study, in-vitro free radical scavenging potential of aqueous extract of Turbinaira ornata (ATO) was evaluated by 1,
1-diphenyl-2-pricrylhydrazyl (DPPH) inhibition assay, Nitric oxide (NO) radical
scavenging assay, lipid peroxide (LPO) inhibition and ABTS radical scavenging
assay. Further, the
anti-inflammatory effect of ATO was evaluated by carrageenan induced paw edema
in rats and vascular permeability assay in mice. ATO showed maximum DPPH and NO
scavenging activity at 500 and 250 µg/mL respectively. Maximum LPO inhibition
was found to be at 62 µg/mL by ATO. Maximum ABTS scavenging assay was found to
be 95.63% at 1000 µg/mL. On the other hand the in-vivo anti-inflammatory activity of the aqueous extract of T.ornata showed a significant (P<0.05)
dose dependent protection at 30, 100, and 300 mg/kg, b.wt. in both carrageenan
induced paw edema and vascular permeability test. Present study reveals that
anti-inflammatory activity of ATO could be due its potential antioxidant and
free radical scavenging property. |
| Page(s): | 664-670 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1033 (Online); 0379-5136 (Print) |
| Source: | IJMS Vol.40(5) [October 2011]
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