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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(11) [November 2011] >
| Title: | Synthesis and antimicrobial studies of Schiff bases of fluoroquinolone |
| Authors: | Patel, Navin B
Patel, Sarvil D
Patel, Arvind L
Patel, Jaymin C
Patel, Jignesh N |
| Keywords: | Schiff base
Fluoroquinolone
Antimicrobial |
| Issue Date: | Nov-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Series
of Schiff bases of fluoroquinolone have been synthesized from lead molecule 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-chloro-3-quinolinecarbonyl
chloride, converted to hydrazide and further reacted with substituted aldehydes
and finally condensed with piperazines, morpholine, imidazole. The title
compounds have been characterized by elemental analysis, IR, 1H NMR spectra. All the synthesized
compounds have been screened for their antimicrobial activity against five
microbes. Majority of them exhibit moderate activity where as good activity has
been observed for S. aureus. |
| Page(s): | 1645-1657 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(11) [November 2011]
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