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Title: Synthesis and antimicrobial studies of Schiff bases of fluoroquinolone
Authors: Patel, Navin B
Patel, Sarvil D
Patel, Arvind L
Patel, Jaymin C
Patel, Jignesh N
Keywords: Schiff base
Issue Date: Nov-2011
Publisher: NISCAIR-CSIR, India
Abstract: Series of Schiff bases of fluoroquinolone have been synthesized from lead molecule 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-chloro-3-quinolinecarbonyl chloride, converted to hydrazide and further reacted with substituted aldehydes and finally condensed with piperazines, morpholine, imidazole. The title compounds have been characterized by elemental analysis, IR, <sup>1</sup>H NMR spectra. All the synthesized compounds have been screened for their antimicrobial activity against five microbes. Majority of them exhibit moderate activity where as good activity has been observed for <i style="">S. </i>aureus.
Description: 1645-1657
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(11) [November 2011]

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