Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/13006
Title: Transforming growth factor <img src='/image/spc_char/beta.gif' border=0> 2: A predictive marker for breast cancer
Authors: Dave, Heena
Trivedi, Sunil
Shah, Manoj
Shukla, Shilin
Keywords: Breast cancer
mRNA
Prognosis
Serum
Survival
TGF-<img src='/image/spc_char/beta.gif' border=0>2
Issue Date: Nov-2011
Publisher: NISCAIR-CSIR, India
Abstract: Dual role of TGF-<img src='/image/spc_char/beta.gif' border=0> signaling in breast tumorigenesis as an inhibitor in early stages and promoter in advanced stages has been well established and known as TGF-<img src='/image/spc_char/beta.gif' border=0> switch. However, the biological mechanisms needs to be explored. Aim of the present study was to look for the usefulness of TGF-<img src='/image/spc_char/beta.gif' border=0>2 as a predictive marker for breast cancer and to offer a better predictability to identify patients likely to benefit from antiTGF-<img src='/image/spc_char/beta.gif' border=0> strategies. Circulatory as well as transcript levels of TGF-<img src='/image/spc_char/beta.gif' border=0>2 were estimated from 118 pretherapeutic breast cancer patients using ELISA and q-PCR with ddCt method. Multifactorial analysis was performed to correlate the results to clinico-pathological prognosticators and Kaplan-Meier survival analysis with a median follow-up of 49 months was also evaluated. Circulating TGF-<img src='/image/spc_char/beta.gif' border=0>2 was similar in control and breast cancer patients. TGF-<img src='/image/spc_char/beta.gif' border=0>2 was significantly upregulated in advanced tumors compared to early tumors. An inverse correlation was observed between TGF-<img src='/image/spc_char/beta.gif' border=0>2 protein and mRNA; nevertheless both exhibited significant correlations with clinico-pathological prognosticators. Higher expression of TGF-<img src='/image/spc_char/beta.gif' border=0>2 mRNA was connected to an early relapse in advanced stage than early stage patients. It is the first report to evaluate circulatory and transcript levels exhibiting TGF-<img src='/image/spc_char/beta.gif' border=0> switch and confirming the utility of TGF-<img src='/image/spc_char/beta.gif' border=0>2 as an important predictive marker for breast cancer.
Description: 879-887
URI: http://hdl.handle.net/123456789/13006
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(11) [November 2011]

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