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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(11) [November 2011] >
| Title: | Transforming growth factor  2: A predictive marker for breast cancer |
| Authors: | Dave, Heena
Trivedi, Sunil
Shah, Manoj
Shukla, Shilin |
| Keywords: | Breast cancer
mRNA
Prognosis
Serum
Survival
TGF-2 |
| Issue Date: | Nov-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Dual role of TGF- signaling in breast tumorigenesis as an inhibitor in
early stages and promoter in advanced stages has been well established and known
as TGF- switch. However, the biological mechanisms needs to be explored. Aim
of the present study was to look for the usefulness of TGF-2 as a predictive
marker for breast cancer and to offer a better predictability to identify
patients likely to benefit from antiTGF- strategies. Circulatory as well as
transcript levels of TGF-2 were estimated from 118 pretherapeutic breast
cancer patients using ELISA and q-PCR with ddCt method. Multifactorial analysis
was performed to correlate the results to clinico-pathological prognosticators
and Kaplan-Meier survival analysis with a median follow-up of 49 months was
also evaluated. Circulating TGF-2 was similar in control and breast cancer patients. TGF-2 was
significantly upregulated in advanced tumors compared to early tumors. An
inverse correlation was observed between TGF-2 protein and mRNA; nevertheless both exhibited significant
correlations with clinico-pathological prognosticators. Higher expression of TGF-2 mRNA was connected to an early relapse in advanced stage than early stage
patients. It is the first report to evaluate circulatory and
transcript levels exhibiting TGF- switch and confirming the utility of TGF-2 as an important
predictive marker for breast cancer. |
| Page(s): | 879-887 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(11) [November 2011]
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