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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(11) [November 2011] >
| Title: | Chemomodulatory potential of Glycine max against murine skin and cervical papillomagenesis |
| Authors: | Singh, M
Mendez, E
Rao, A Ramesha
Kale, R K |
| Keywords: | Biotransformation enzyme system
Chemoprevention
Glycine max
Papillomagenesis |
| Issue Date: | Nov-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | In
the present study, chemopreventive potential of Glycine max (G. Max) seeds was examined against DMBA-induced skin
and MCA-induced cervical papillomagenesis in Swiss albino mice. Different doses
(2.5, 5, and 7.5% w/w) of G. max were
provided to animals in feed. Results exhibited a significant reduction in skin
as well as cervical tumor incidence and tumor multiplicity (up to 75%) at all
doses of test diet as compared to the control. Relatively, 7.5% test diet was
most effective in protecting the animals against carcinogenesis. Further, detoxifying
enzymes and antioxidative status was also evaluated in the liver of mice to
understand the role of G. max in
prevention of cancer. It was observed that the test diet containing G. max significantly elevated the
specific activities of glutathione-S-transferase (GST), DT-diaphorase (DTD),
superoxide dismutase (SOD), catalase (CAT), and glyoxalase I (Gly I). The test
diet also elevated the content of reduced glutathione whereas it decreased the
level of the peroxidative damage along with the specific activity of lactate
dehydrogenase. It appeared that G. max
seeds provided chemoprevention against skin and cervical papillomagenesis
probably by modulating the detoxifying and antioxidative enzymes. It could be
inferred that intake of G. max might
help in reducing the risk of cancer. |
| Page(s): | 864-870 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(11) [November 2011]
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