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Title: Chemoprotective influence of <i style="">Zanthoxylum</i> sps. on hepatic carcinogen metabolizing and antioxidant enzymes and skin papillomagenesis in murine model
Authors: Rajamani, Paulraj
Banerjee, Sanjeev
Rao, A Ramesha
Keywords: Antioxidant enzymes
Xenobiotic detoxification
<i style="">Zanthoxylum </i>sps
Issue Date: Nov-2011
Publisher: NISCAIR-CSIR, India
Abstract: In the present study, the putative potential of pericarp of dried fruit of <i style="">Zanthoxylum</i> (Rutaceae Family), a common spice additive in India’s west coast cuisines, in protecting against carcinogenesis has been reported. Extract from dried fruit of <i style="">Zanthoxylum</i> was orally administered to mice at two dose levels: 100 and 200 mg/kg body wt. for 14 days. Results reveal bifunctional nature of <i style="">Zanthoxylum</i> species as deduced from its potential to induce phase-I and phase-II enzyme activities associated with carcinogen activation and detoxification in the liver of mice. Hepatic glutathione S-transferase and DT-diaphorase were found significantly elevated by the treatment. <i style="">Zanthoxylum</i> was also effective in augmenting the antioxidant enzyme activities of glutathione peroxidase, superoxide dismutase and catalase albeit significantly by high dose of the extract (<i style="">P</i><0.05; <i style="">P</i><0.01). Reduced glutathione was also significantly elevated in the liver of treated animals (<i style="">P</i><0.05). The present study also investigated peri-initiation application of acetone extract of <i style="">Zanthoxylum</i> on initiated mouse skin. Results showed a significant reduction in tumor incidence from 68% to 36% (<i style="">P</i><0.05); as well as, a reduction in tumor burden per effective mouse from 3.87 to 0.72 (<i style="">P</i><0.01). Cumulatively, the findings strongly suggest cancer chemo-preventive potential of <i style="">Zanthoxylum</i> sps.
Description: 857-863
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(11) [November 2011]

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