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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(11) [November 2011] >
| Title: | Chemoprotective influence of Zanthoxylum sps. on hepatic carcinogen metabolizing and antioxidant enzymes and skin papillomagenesis in murine model |
| Authors: | Rajamani, Paulraj
Banerjee, Sanjeev
Rao, A Ramesha |
| Keywords: | Antioxidant enzymes
Chemoprevention
Xenobiotic detoxification
Zanthoxylum sps |
| Issue Date: | Nov-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | In the present study, the putative potential of pericarp of dried
fruit of Zanthoxylum (Rutaceae
Family), a common spice additive in India’s west coast cuisines, in
protecting against carcinogenesis has been reported. Extract from dried fruit
of Zanthoxylum was orally administered
to mice at two dose levels: 100 and 200 mg/kg body wt. for 14 days. Results
reveal bifunctional nature of Zanthoxylum
species as deduced from its potential to induce phase-I and phase-II enzyme
activities associated with carcinogen activation and detoxification in the
liver of mice. Hepatic glutathione S-transferase and
DT-diaphorase were found significantly elevated by the treatment. Zanthoxylum was also effective in
augmenting the antioxidant enzyme activities of glutathione peroxidase,
superoxide dismutase and catalase albeit significantly by high dose of the
extract (P<0.05; P<0.01). Reduced glutathione was also
significantly elevated in the liver of treated animals (P<0.05). The present study also investigated peri-initiation
application of acetone extract of Zanthoxylum
on initiated mouse skin. Results showed a significant reduction in tumor
incidence from 68% to 36% (P<0.05);
as well as, a reduction in tumor burden per effective mouse from 3.87 to 0.72 (P<0.01). Cumulatively, the findings
strongly suggest cancer chemo-preventive potential of Zanthoxylum sps. |
| Page(s): | 857-863 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(11) [November 2011]
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