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Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(11) [November 2011] >
| Title: | Potential molecular targeting of splice variants for cancer treatment |
| Authors: | Blair, Christopher A
Zi, Xiaolin |
| Keywords: | Cancer therapeutics
Expressed sequence tags
Osteopontin-c
SiRNA
Tumour specific splice variants |
| Issue Date: | Nov-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Array of new targets for investigation as
cancer therapeutics has great potential to grow as new splice-variants are
identified and characterized in cancer cell-lines and tumor samples. Tumor-specific
splice variants are being discovered at an increasing rate and their functions
are also investigated in cancer progression. The tumor-specific splice variants
whose expression patterns and activities are successfully characterized may
become attractive targets for ablation or splicing modification. The extreme
specificity of their expression suggests that a variant-specific treatment may
allow for targeting of cancerous cells with minimal impact to healthy tissues. Clinical
investigation of applying antisense oligonucleotides to down-regulate mRNAs
that contribute to cancer cell survival and to modify splicing patterns in
muscular dystrophy has shown promising results. These results show that
antisense therapy may be applied effectively and safely in humans. As these
treatment strategies continue to improve and novel tumor-specific
splice-variants are identified, modification of splicing patterns will become
an important field of investigation to develop more effective and safe cancer
therapies. |
| Page(s): | 836-839 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(11) [November 2011]
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