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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(11) [November 2011] >
| Title: | Molecular mechanisms and targets of cancer chemoprevention by garlic-derived bioactive compound diallyl trisulfide |
| Authors: | Antony, Marie Lue
Singh, Shivendra V |
| Keywords: | Apoptosis
Chemoprevention
Diallyl trisulfide
Garlic |
| Issue Date: | Nov-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Health
benefits of garlic and other Allium vegetables
(e.g., onions), such as lipid lowering and anticancer effects, are credited to
metabolic byproducts, including diallyl trisulfide (DATS). Evidence for
anticancer effects of garlic derives from both population-based case-control
studies, and clinical and laboratory investigations using purified garlic
constituents such as DATS. Studies have shown that DATS can offer protection
against chemically-induced neoplasia as well as oncogene-driven spontaneous
cancer development in experimental rodents. Mechanisms underlying cancer
chemopreventive effects of DATS are not completely understood, but known
pharmacological responses to this natural product include alteration in
carcinogen-metabolizing enzymes, cell cycle arrest, induction of apoptotic cell
death, suppression of oncogenic signal transduction pathways, and inhibition of
neoangiogenesis. This article reviews mechanisms and targets of cancer
chemoprevention by DATS. |
| Page(s): | 805-816 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(11) [November 2011]
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