Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/12982
Title: Biocatalytic route for the synthesis of active pharmaceutical diol: A greener approach
Authors: Meena, Vachan Singh
Banerjee, U C
Keywords: Biocatalysis
Biotransformation
Candida viswanathii
Epoxide hydrolase
Phenyl glycidyl ether
3-phenoxy-1,2-propane diols
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Abstract: Candida viswanathii was employed for the synthesis of an active pharmaceutical diol from epoxide. Studies on the culture conditions for the production of epoxide hydrolase by C. viswanathii revealed that cultivation temperature of 30°C and medium pH 7 enhanced the enzyme production. The reaction conditions for the epoxide hydrolysis were optimized and the optimal temperature and pH were found to be 30°C and 8, respectively. The optimized reaction time and mixing rate were 15 h and 200 rpm, respectively. Ethanol was found to be a good co-solvent. More than 90% conversion was obtained with these optimized conditions. The product formation progress was monitored by HPLC; the product was characterized by NMR and MASS spectroscopy.
Description: 452-457
URI: http://hdl.handle.net/123456789/12982
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.10(4) [October 2011]

Files in This Item:
File Description SizeFormat 
IJBT 10(4) 452-457.pdf266.84 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.