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Title: Biocatalytic route for the synthesis of active pharmaceutical diol: A greener approach
Authors: Meena, Vachan Singh
Banerjee, U C
Keywords: Biocatalysis
<i>Candida viswanathii</i>
Epoxide hydrolase
Phenyl glycidyl ether
3-phenoxy-1,2-propane diols
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Abstract: <i>Candida viswanathii </i>was employed for the synthesis of an active pharmaceutical diol from epoxide. Studies on the culture conditions for the production of epoxide hydrolase by <i>C. viswanathii </i>revealed that cultivation temperature of 30°C and medium <i>p</i>H 7 enhanced the enzyme production. The reaction conditions for the epoxide hydrolysis were optimized and the optimal temperature and <i>p</i>H were found to be 30°C and 8, respectively. The optimized reaction time and mixing rate were 15 h and 200 rpm, respectively. Ethanol was found to be a good co-solvent. More than 90% conversion was obtained with these optimized conditions. The product formation progress was monitored by HPLC; the product was characterized by NMR and MASS spectroscopy.
Description: 452-457
ISSN: 0975-0967 (Online); 0972-5849 (Print)
Appears in Collections:IJBT Vol.10(4) [October 2011]

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