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Indian Journal of Biotechnology (IJBT) >
IJBT Vol.10 [2011] >
IJBT Vol.10(4) [October 2011] >
| Title: | Metabolism of cyclic-di-GMP in bacterial biofilms: From a general overview to biotechnological applications |
| Authors: | Castiglione, Nicoletta
Stelitano, Valentina
Rinaldo, Serena
Giardina, Giorgio
Caruso, Manuela
Cutruzzolà, Francesca |
| Keywords: | Biofilm
Cyclic-di-GMP
Inhibitors
Pathogenesis
PDE
DGC |
| Issue Date: | Oct-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Bacteria exist in nature in
a planktonic single-cell state or in a sessile multicellular state, the biofilm.
In the latter state, the bacterial community optimizes the cell-environment and
cell to cell communication strategies. Biofilms are widely diffuse in many
industrial, environmental and clinical settings and are less sensitive to
treatments with antimicrobial agents compared to planktonic cells. Biofilms
formed by bacterial pathogens, such as, those formed by Pseudomonas aeruginosa in immunocompromised patients, have a high
impact on public health. The switch between the planktonic and the biofilm
lifestyle is strictly regulated by the second messenger 3', 5'-cyclic
diguanylic acid (c-di-GMP). The intracellular levels of this molecule are
controlled by two classes of enzymes: diguanylate cyclases (DGC) and
phosphodiesterases (PDE). In this review, we report the structural and
functional data available to date on these enzymes and we summarize the
possible medical, environmental and industrial biotechnological applications
involving bacterial c-di-GMP metabolism. |
| Page(s): | 423-431 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0967 (Online); 0972-5849 (Print) |
| Source: | IJBT Vol.10(4) [October 2011]
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