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Indian Journal of Biotechnology (IJBT) >
IJBT Vol.10 [2011] >
IJBT Vol.10(4) [October 2011] >
| Title: | Synthesis, characterization and cytotoxicity of new Ho(III) and Er(III) complexes |
| Authors: | Kostova, Irena
Grigorov, Petar
Balkansky, Stefan
Stefanova, Tsvetanka |
| Keywords: | Coumarins
Cytotoxic/cytostatic activity
Er(III)
FT-IR
FT-Raman
Ho(III) |
| Issue Date: | Oct-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | New complexes of
coumarin-3-carboxylic acid (HCCA) with holmium [Ho(III)] and erbium [Er(III)]
were synthesized and their structures and spectral properties were investigated
by elemental analysis, IR, Raman and NMR measurements. According to the
experimental data of the complexes, their formulae and geometries have been
suggested. Vibrational frequencies, IR intensities and Raman activities as well
as 1H NMR chemical shifts of HCCA and its lanthanum [Ln(III)]
complexes are presented. The comparative experimental spectral analyses of both
the ligand and the Ln(III) complexes predicted the bidentate binding to Ho(III)
and Er(III) through the deprotonated carboxylic oxygen and the carbonylic
oxygen of the ligand. The cytotoxic/cytostatic properties of the ligand and the
newly synthesized complexes of coumarin-3-carboxylic acid with Ho(III) and
Er(III) were tested by MTT reduction assay against two mouse tumour cell lines,
melanoma B16 and fibrosarcoma L929, as well as against normal mouse peritoneal
macrophages. The proliferation inhibitory effect of the complexes compared to
that of the ligand proved their cytotoxic/cytostatic properties against both
the tumour cell lines. The complexes were less cytotoxic against normal mouse
macrophages and modulated NO release by activated macrophages. The results are
in accordance with our previously published data on the activity of lanthanide (III)
complexes with coumarins. |
| Page(s): | 387-394 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0967 (Online); 0972-5849 (Print) |
| Source: | IJBT Vol.10(4) [October 2011]
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