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JSIR Vol.66 [2007] >
JSIR Vol.66(08) [August 2007] >
| Title: | Bio-active conjugates of curcumin having ester, peptide, thiol and disulfide links |
| Authors: | Kapoor, Neha
Narain, Upma
Misra, Krishna |
| Keywords: | Bioconjugates
Curcumin |
| Issue Date: | Aug-2007 |
| Publisher: | CSIR |
| Abstract: | Mixed bioconjugates of curcumin [4,4’-di-O-(glycinoyl-cystinoyl) curcumin, 4,4’-di- O-(glycinoyl-cysteinoyl) curcumin,
4,4’-di-O-L-(alaninoyl) curcumin, 4,4’-di-(O- glycinoyl)—glycinoyl) curcumin and 4,4’-di-O{(3,4,5-O-acetyl) galloyl} curcumin]
have been prepared and characterized. These bioconjugates contain biodegradable (ester and peptide) bonds and have been
tested for antifungal and anti bacterial activities, which have been found to be considerably enhanced vis-à-vis curcumin. The
plausible reasons for this remarkable enhancement in therapeutic activity may be due to better cellular uptake, increased cellular
concentration, better receptor binding at the target sites due to extended conjugation. These conjugates may act as potent
prodrugs since these can get enzymatically hydrolysed at the target sites. |
| Page(s): | 647-650 |
| ISSN: | 0022-4456 |
| Source: | JSIR Vol.66(08) [August 2007]
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