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Title: Antioxidant properties of hydroxytyrosyl acetate compared with hydroxytyrosol and their protective capacity against oxidative stress in human neuroblastoma cells
Authors: Ammendola, Sergio
Giusti, Anna M
Masci, Alessandra
Mosca, Luciana
Saso, Luciano
Bovicelli, Paolo
Keywords: Antioxidants;Hydroxytyrosol (HTy);Hydroxytyrosyl acetate (HTy-ac);Neuroblastoma cell line;Olive oil;Oxidative stress
Issue Date: Nov-2011
Publisher: NISCAIR-CSIR, India
Abstract: This study analyses antioxidant activity of synthetic hydroxytyrosol (HTy) and hydroxytyrosyl acetate (HTy-ac) against different reactive species. Both phenols were found to be able to scavenge superoxide anion as well as hydroxyl radical with comparable efficacy (40% and 80% scavenging activity, respectively). HTy-ac was found to be more effective than HTy or a-tocopherol as hydrogen peroxide scavenger (53%, 29% and 25% scavenging activity, respectively) (p£0.05). Human neuroblastoma cell line SH-SY5Y was chosen as an ex vivo model and cellular oxidative stress was assessed through the measurement of total free sulfhydryl groups and protein carbonyls. HTy displayed a high antioxidant ability against thiols oxidation at 10 M, whereas HTy-ac showed a great capacity in preventing carbonyl groups generation. Different antioxidant ability showed by tested compounds against oxidative stress in biological system can be attributed to molecular concentration, reducing power and lipophilicity.
Page(s): 929-937
ISSN: 0975-1084 (Online); 0022-4456 (Print)
Appears in Collections:JSIR Vol.70(11) [November 2011]

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