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JSIR Vol.70 [2011] >
JSIR Vol.70(11) [November 2011] >
| Title: | Antioxidant properties of hydroxytyrosyl acetate compared with hydroxytyrosol and their protective capacity against oxidative stress in human neuroblastoma cells |
| Authors: | Ammendola, Sergio
Giusti, Anna M
Masci, Alessandra
Mosca, Luciana
Saso, Luciano
Bovicelli, Paolo |
| Keywords: | Antioxidants
Hydroxytyrosol (HTy)
Hydroxytyrosyl acetate (HTy-ac)
Neuroblastoma cell line
Olive oil
Oxidative stress |
| Issue Date: | Nov-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | This study analyses antioxidant activity of synthetic
hydroxytyrosol (HTy) and hydroxytyrosyl acetate (HTy-ac) against
different reactive species. Both phenols were found to
be able to scavenge superoxide anion as well as hydroxyl radical with
comparable efficacy (40% and 80% scavenging activity,
respectively). HTy-ac was found to be more effective than HTy or
a-tocopherol as hydrogen peroxide scavenger (53%, 29%
and 25% scavenging activity, respectively) (p£0.05). Human
neuroblastoma cell line SH-SY5Y was chosen as an ex
vivo model and cellular oxidative stress was assessed through the
measurement of total free sulfhydryl groups and protein
carbonyls. HTy displayed a high antioxidant ability against thiols
oxidation at 10  M, whereas HTy-ac showed a great capacity in preventing carbonyl groups
generation. Different antioxidant
ability showed by tested compounds against oxidative
stress in biological system can be attributed to molecular concentration,
reducing power and
lipophilicity. |
| Page(s): | 929-937 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1084 (Online); 0022-4456 (Print) |
| Source: | JSIR Vol.70(11) [November 2011]
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