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Title: Sodium selenite attenuated cisplatin-induced toxicity in rats: Role of electrolytes homeostasis
Authors: Noori, Shafaq
Mahboob, Tabassum
Keywords: Cisplatin;Electrolytes homeostasis;Na+ K+ ATPase;Sodium selenite
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Abstract: Sodium selenite (1 mg/kg body weight, ip) for 10 consecutive days treatment showed marked increase in intra-erythrocytes K+ and plasma Na+ level while slight increase in Na+ K+ ATPase level. No mortality was observed at this dose of sodium selenite. However, sodium selenite pretreatment partially restored the Na+ K+ ATPase and intra-erythorcytes and plasma sodium level, while completely restored the intra-erythrocytes K+ and plasma Mg2+ level. No change was observed in plasma Ca2+ level. Thus sodium selenite successively attenuated the Cisplatin-induced electrolytes alterations and toxicity by exerting the stress response of sodium.
Page(s): 791-794
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(10) [October 2011]

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