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|Title:||Sodium selenite attenuated cisplatin-induced toxicity in rats: Role of electrolytes homeostasis|
Na+ K+ ATPase
|Abstract:||Sodium selenite (1 mg/kg body weight, ip) for 10 consecutive days treatment showed marked increase in intra-erythrocytes K<sup>+</sup> and plasma Na<sup>+</sup> level while slight increase in Na<sup>+ </sup>K<sup>+</sup> ATPase level. No mortality was observed at this dose of sodium selenite. However, sodium selenite pretreatment partially restored the Na<sup>+</sup> K<sup>+</sup> ATPase and intra-erythorcytes and plasma sodium level, while completely restored the intra-erythrocytes K<sup>+ </sup>and plasma Mg<sup>2+ </sup>level. No change was observed in plasma Ca<sup>2+</sup> level. Thus sodium selenite successively attenuated the Cisplatin-induced electrolytes alterations and toxicity by exerting the stress response of sodium.|
|ISSN:||0975-1009 (Online); 0019-5189 (Print)|
|Appears in Collections:||IJEB Vol.49(10) [October 2011]|
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