Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/12869
Title: Sodium selenite attenuated cisplatin-induced toxicity in rats: Role of electrolytes homeostasis
Authors: Noori, Shafaq
Mahboob, Tabassum
Keywords: Cisplatin
Electrolytes homeostasis
Na+ K+ ATPase
Sodium selenite
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Abstract: Sodium selenite (1 mg/kg body weight, ip) for 10 consecutive days treatment showed marked increase in intra-erythrocytes K<sup>+</sup> and plasma Na<sup>+</sup> level while slight increase in Na<sup>+ </sup>K<sup>+</sup> ATPase level. No mortality was observed at this dose of sodium selenite. However, sodium selenite pretreatment partially restored the Na<sup>+</sup> K<sup>+</sup> ATPase and intra-erythorcytes and plasma sodium level, while completely restored the intra-erythrocytes K<sup>+ </sup>and plasma Mg<sup>2+ </sup>level. No change was observed in plasma Ca<sup>2+</sup> level. Thus sodium selenite successively attenuated the Cisplatin-induced electrolytes alterations and toxicity by exerting the stress response of sodium.
Description: 791-794
URI: http://hdl.handle.net/123456789/12869
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(10) [October 2011]

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