NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(10) [October 2011] >

Title: Antihyperglycemic and antioxidative attribute of hydroethanolic extract of Butea monosperma (Lam.) seeds and its active constituents
Authors: Sharma, Nidhi
Garg, Veena
Keywords: Antihyperglycemic
Butea monosperma
Laccijalaric ester-I
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Abstract: Treatment of diabetic mice with glibenclamide and crude extract (BE) significantly declined the FBG content. However, amongst the 6 isolated compounds, 3 compounds (C1, C4 and C6) appreciably subsided the exaggerated level of FBG. Simultaneously, glibenclamide, BE, C4 and C6 treatment markedly enhanced the hepatic glycogen content as compared to diabetic control group. Administration of crude extract, C4, C5 and C6 also exerted a protective effect on the declined activity of SOD, CAT and GSH-Px in the three tissues. However, all the herbal treatments produced a pronounced escalation in GSH content. Contrarily the elevated level of hepatic, pancreatic and renal TBARS monitored in diabetic animals was significantly diminished in treated groups of animals. Alloxan administration severely deteriorated the structure of liver and pancreas of diabetic mice, which was found to be restored to a certain extent in glibenclamide, BE and C6 treated animals. Identification of the most potent antihyperglycemic compound C6 by HPLC confirmed its triterpene nature. C6 was then further characterized via various spectroscopic methods (IR, NMR and Mass) that revealed its similarity with laccijalaric ester-I, a triterpene present in soft resin of B. monosperma seeds.
Page(s): 756-766
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Source:IJEB Vol.49(10) [October 2011]

Files in This Item:

File Description SizeFormat
IJEB 49(10) 756-766.pdf807.17 kBAdobe PDFView/Open
 Current Page Visits: 133 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 169385 since 01-Sep-2015  Last updated on 30-Jun-2016Webmaster: