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Title: <i>Spirulina platensis</i> protects neurons via suppression of glial activation and peripheral sensitization leading to restoration of motor function in collagen-induced arthritic rats
Authors: Patro, Nisha
Sharma, Arpita
Kariaya, Keerti
Patro, Ishan
Keywords: Collagen-induced arthritis
Spinal cord
<i>Spirulina platensis</i>
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Abstract: <i>Spirulina</i> <i style="">platensis</i> treatment (400 mg kg<sup>-1</sup> for 25 days) effectively suppressed peripheral sensitization via modulation of glial activation and improved motor coordination and restoration of functional motor activity in collagen-induced arthritic rats. <i>Spirulina</i> treatment also resulted in an appreciable reduction of the NF200 accumulation in the spinal cord neurons of arthritic rats. This is indicative of neuroprotective action of <i>S.</i> <i style="">platensis</i> against glutamate excitotoxicity-induced central sensitization produced by the peripheral joint inflammation in the collagen-induced arthritis. The results suggest that effects of <i>S.</i> <i style="">platensis</i> may be due to its counter regulation of spinal glial activation and could be a potential strategy for the treatment of arthritis.
Description: 739-748
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.49(10) [October 2011]

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