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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(10) [October 2011] >
| Title: | Spirulina platensis protects neurons via suppression of glial activation and peripheral sensitization leading to restoration of motor function in collagen-induced arthritic rats |
| Authors: | Patro, Nisha
Sharma, Arpita
Kariaya, Keerti
Patro, Ishan |
| Keywords: | Collagen-induced arthritis
Microglia
Neuroprotection
Spinal cord
Spirulina platensis |
| Issue Date: | Oct-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Spirulina platensis treatment (400
mg kg-1 for 25 days) effectively suppressed peripheral sensitization
via modulation of glial activation and improved motor coordination and
restoration of functional motor activity in collagen-induced arthritic rats. Spirulina
treatment also resulted in an appreciable reduction of the NF200 accumulation
in the spinal cord neurons of arthritic rats. This is indicative of
neuroprotective action of S. platensis
against glutamate excitotoxicity-induced central sensitization produced by the
peripheral joint inflammation in the collagen-induced arthritis. The results
suggest that effects of S. platensis
may be due to its counter regulation of spinal glial activation and could be a
potential strategy for the treatment of arthritis. |
| Page(s): | 739-748 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(10) [October 2011]
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