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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(10) [October 2011] >
| Title: | Tocotrienols: The lesser known form of natural vitamin E |
| Authors: | Patel, Viren
Rink, Cameron
Khanna, Savita
Sen, Chandan K |
| Keywords: | Arteriogenesis
MMP2
Neuroprotection
TIMP1
Tocotrienols
Vitamin E |
| Issue Date: | Oct-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | A recent and growing body of research has shown that members of this
vitamin E family posses unique biologic functions. Tocotrienols have garnered
much of this recent attention, and in particular a-tocotrienol has been shown
to be the most potent neuroprotective form of vitamin E. Protection exclusively
mediated through tocotrienols has been arbitrated to many mechanisms including
inhibition of 12-LOX, c-Src, PLA2 and through up-regulation of MRP1.
Further, tocotrienols have recently been shown to induce arteriogenesis through
induction of TIMP1 and decreased activation of MMP2. However, the unique
therapeutic potential of tocotrienols is not limited to neuroprotection.
Tocotrienols have been shown to have molecular targets including: apoptotic
regulators, cytokines, adhesion molecules, enzymes, kinases, receptors,
transcription factors, and growth factors. In spite of this large and unique
therapeutic potential, scientific literature on tocotrienols only accounts for
approximately 1% of vitamin E research. Given the potential of tocotrienols and
relatively scant literature, further investigation is warranted. |
| Page(s): | 732-738 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(10) [October 2011]
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