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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.49 [2011] >
IJEB Vol.49(10) [October 2011] >
| Title: | Dynamic life of a skin keratinocyte: An intimate tryst with the master regulator p63 |
| Authors: | Romano, Rose-Anne
Sinha, Satrajit |
| Keywords: | Hair follicles
Keratinocyte
Skin
 Np63, p53 |
| Issue Date: | Oct-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | Skin keratinocytes form a tightly knit and
layered epithelium at the surface of the body protecting the body from the
outside environment. The formation and maintenance of skin epidermis is
governed by dynamic and well-coordinated processes of cell proliferation,
differentiation, and self-renewal. Such important cell fate decisions are made
possible in part by transcription factors, which activate and repress unique
sets of genes in a temporal and spatial pattern. The Tp63 gene encodes for multiple isoforms for one such transcription
factor that serves as a key regulator of epidermal development and
differentiation. The crucial function of p63 is epitomized by the phenotype of p63 knockout mice – in the absence of
p63, there is a profound block in the development of skin epidermis and all
related appendages such as hair follicles. Human syndromes resulting from Tp63 gene mutations phenocopy the p63 knockout phenotype, highlighting the
evolutionarily conserved function of this factor in epithelial biology.
Although the function of p63 as an important hub in transcriptional and
signaling networks of keratinocytes is well established, the underlying
molecular mechanisms of p63 action is continually redefined with the
development of new genetic models and more extensive biochemical analysis. In
this review the biological role of Np63, the predominant isoform that is
expressed in skin keratinocytes has been described. Results from transgenic
animal models that have shed new information on the function of Np63 in the
epidermis and hair follicles have been discussed. Further, the molecular
mechanisms that maintain the fine-tuned expression of Np63 in skin
keratinocytes are also described. |
| Page(s): | 721-731 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.49(10) [October 2011]
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