Synthesis of some 3-(5-chloro-1,3-diaryl-1<i style="">H</i>-pyrazol-4-yl)-1-arylprop-2-en-1-ones and 1,5-bis(5-chloro-1,3-diaryl-1<i style="">H</i>-pyrazol-4-yl)pent-1,4-diene-3-ones and their antimicrobial activity

Abstract

New 3-(5-chloro-1,3-diaryl-1<i style="">H</i>-pyrazol-4-yl)-1-arylprop-2-en-1-ones (<b style="">4a-n</b>) and 1,5-bis(5-chloro-1,3-diaryl-1<i style="">H</i>-pyrazol-4-yl)pent-1,4-diene-3-ones (<b style="">4o-r</b>) have been synthesized by using aryl-5-chloro-4-formyl-1,2-pyrazoles (<b style="">2a-d</b>) as key intermediate, prepared by Vilsmeir-Haack reaction of pyrazolones. The compounds have been screened against multihost plant pathogenic fungi <i>Macrophomina phaseolina</i><i style=""> </i>and <i style="">Sclerotium rolfsii</i> and human pathogenic bacteria MTCCB 96 <i style="">Staphylococcus aureus</i>, MTCCB 1610 <i style="">Escherichia coli</i>, clinical isolate <i style="">Citrobacter Sp. </i>and <i style="">Enterococcus faecium</i>. Some compounds have shown promising activity against these microbes. Regression analysis has also been done for relationship between antifungal activity and concentra­tion of compounds.