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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.50B [2011] >
IJC-B Vol.50B(10) [October 2011] >
| Title: | Synthesis of some 3-(5-chloro-1,3-diaryl-1H-pyrazol-4-yl)-1-arylprop-2-en-1-ones and 1,5-bis(5-chloro-1,3-diaryl-1H-pyrazol-4-yl)pent-1,4-diene-3-ones and their antimicrobial activity |
| Authors: | Rani, Archna
Jain, Sapna
Dureja, Prem
Kumar, Rita
Kumar, Anil |
| Keywords: | Chalcone
Antibacterial agent
Antifungal agent
MIC
 ,  -unsaturated carbonyl compounds |
| Issue Date: | Oct-2011 |
| Publisher: | NISCAIR-CSIR, India |
| Abstract: | New
3-(5-chloro-1,3-diaryl-1H-pyrazol-4-yl)-1-arylprop-2-en-1-ones
(4a-n) and
1,5-bis(5-chloro-1,3-diaryl-1H-pyrazol-4-yl)pent-1,4-diene-3-ones
(4o-r) have been synthesized by
using aryl-5-chloro-4-formyl-1,2-pyrazoles (2a-d) as key intermediate, prepared by Vilsmeir-Haack reaction of
pyrazolones. The compounds have been screened against multihost plant
pathogenic fungi Macrophomina phaseolina and Sclerotium rolfsii and
human pathogenic bacteria MTCCB 96 Staphylococcus
aureus, MTCCB 1610 Escherichia coli,
clinical isolate Citrobacter Sp. and Enterococcus faecium. Some compounds
have shown promising activity against these microbes. Regression analysis has
also been done for relationship between antifungal activity and concentration
of compounds. |
| Page(s): | 1524-1531 |
| CC License: |  CC Attribution-Noncommercial-No Derivative Works 2.5 India |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.50B(10) [October 2011]
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