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IJC-B Vol.50B(10) [October 2011] >


Title: Synthesis of some 3-(5-chloro-1,3-diaryl-1H-pyrazol-4-yl)-1-arylprop-2-en-1-ones and 1,5-bis(5-chloro-1,3-diaryl-1H-pyrazol-4-yl)pent-1,4-diene-3-ones and their antimicrobial activity
Authors: Rani, Archna
Jain, Sapna
Dureja, Prem
Kumar, Rita
Kumar, Anil
Keywords: Chalcone
Antibacterial agent
Antifungal agent
MIC
, -unsaturated carbonyl compounds
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Abstract: New 3-(5-chloro-1,3-diaryl-1H-pyrazol-4-yl)-1-arylprop-2-en-1-ones (4a-n) and 1,5-bis(5-chloro-1,3-diaryl-1H-pyrazol-4-yl)pent-1,4-diene-3-ones (4o-r) have been synthesized by using aryl-5-chloro-4-formyl-1,2-pyrazoles (2a-d) as key intermediate, prepared by Vilsmeir-Haack reaction of pyrazolones. The compounds have been screened against multihost plant pathogenic fungi Macrophomina phaseolina and Sclerotium rolfsii and human pathogenic bacteria MTCCB 96 Staphylococcus aureus, MTCCB 1610 Escherichia coli, clinical isolate Citrobacter Sp. and Enterococcus faecium. Some compounds have shown promising activity against these microbes. Regression analysis has also been done for relationship between antifungal activity and concentra¬≠tion of compounds.
Page(s): 1524-1531
CC License:  CC Attribution-Noncommercial-No Derivative Works 2.5 India
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.50B(10) [October 2011]

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