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Title: Synthesis of some 3-(5-chloro-1,3-diaryl-1<i style="">H</i>-pyrazol-4-yl)-1-arylprop-2-en-1-ones and 1,5-bis(5-chloro-1,3-diaryl-1<i style="">H</i>-pyrazol-4-yl)pent-1,4-diene-3-ones and their antimicrobial activity
Authors: Rani, Archna
Jain, Sapna
Dureja, Prem
Kumar, Rita
Kumar, Anil
Keywords: Chalcone
Antibacterial agent
Antifungal agent
<img src='' border=0>, <img src='' border=0>-unsaturated carbonyl compounds
Issue Date: Oct-2011
Publisher: NISCAIR-CSIR, India
Abstract: New 3-(5-chloro-1,3-diaryl-1<i style="">H</i>-pyrazol-4-yl)-1-arylprop-2-en-1-ones (<b style="">4a-n</b>) and 1,5-bis(5-chloro-1,3-diaryl-1<i style="">H</i>-pyrazol-4-yl)pent-1,4-diene-3-ones (<b style="">4o-r</b>) have been synthesized by using aryl-5-chloro-4-formyl-1,2-pyrazoles (<b style="">2a-d</b>) as key intermediate, prepared by Vilsmeir-Haack reaction of pyrazolones. The compounds have been screened against multihost plant pathogenic fungi <i>Macrophomina phaseolina</i><i style=""> </i>and <i style="">Sclerotium rolfsii</i> and human pathogenic bacteria MTCCB 96 <i style="">Staphylococcus aureus</i>, MTCCB 1610 <i style="">Escherichia coli</i>, clinical isolate <i style="">Citrobacter Sp. </i>and <i style="">Enterococcus faecium</i>. Some compounds have shown promising activity against these microbes. Regression analysis has also been done for relationship between antifungal activity and concentra¬≠tion of compounds.
Description: 1524-1531
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.50B(10) [October 2011]

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